Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/191362
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dc.titleEpigenetic plasticity and redox regulation of neural stem cell state and fate
dc.contributor.authorEMMY TAY XUE YUN
dc.contributor.authorCHIA KIMBERLY
dc.contributor.authorONG SEK TONG, DERRICK
dc.date.accessioned2021-05-20T04:45:42Z
dc.date.available2021-05-20T04:45:42Z
dc.date.issued2021-03-06
dc.identifier.citationEMMY TAY XUE YUN, CHIA KIMBERLY, ONG SEK TONG, DERRICK (2021-03-06). Epigenetic plasticity and redox regulation of neural stem cell state and fate. Free Radical Biology and Medicine. ScholarBank@NUS Repository.
dc.identifier.issn0891-5849
dc.identifier.issn1873-4596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/191362
dc.description.abstractThe neural stem cells (NSCs) are essential for normal brain development and homeostasis. The cell state (i.e. quiescent versus activated) and fate (i.e. the cell lineage of choice upon differentiation) of NSCs are tightly controlled by various redox and epigenetic regulatory mechanisms. There is an increasing appreciation that redox and epigenetic regulations are intimately linked, but how this redox-epigenetics crosstalk affects NSC activity remains poorly understood. Another unresolved topic is whether the NSCs actually contribute to brain ageing and neurodegenerative diseases. In this review, we aim to 1) distill concepts that underlie redox and epigenetic regulation of NSC state and fate; 2) provide examples of the redox-epigenetics crosstalk in NSC biology; and 3) highlight potential redox- and epigenetic-based therapeutic opportunities to rescue NSC dysfunctions in ageing and neurodegenerative diseases.
dc.publisherElsevier BV
dc.sourceElements
dc.subjectAgeing
dc.subjectAlzheimer's disease
dc.subjectEpigenetics
dc.subjectMetabolism
dc.subjectNeural stem cells
dc.subjectReactive oxygen species
dc.subjectRedox
dc.typeArticle
dc.date.updated2021-05-20T04:09:57Z
dc.contributor.departmentPHYSIOLOGY
dc.description.sourcetitleFree Radical Biology and Medicine
dc.published.statePublished
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