Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jns.2009.08.066
Title: A serotoninergic basis for hyperphagic eating changes in Alzheimer's disease
Authors: Tsang, Shirley W 
Keene, Janet
Hope, Tony
Spence, Ian
Francis, Paul T
Wong, Peter T-H 
Chen, Christopher P 
Lai, Mitchell K 
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences
Neurosciences & Neurology
Alzheimer's disease
Dementia
Hyperphagia
Serotonin receptor
Serotonin transporter
Neocortex
POSITRON-EMISSION-TOMOGRAPHY
5-HT1A RECEPTOR-BINDING
FRONTOTEMPORAL DEMENTIA
BEHAVIORAL-CHANGES
COGNITIVE DECLINE
ANOREXIA-NERVOSA
FEEDING-BEHAVIOR
NATURAL-HISTORY
BULIMIA-NERVOSA
TEMPORAL-LOBE
Issue Date: 15-Jan-2010
Publisher: ELSEVIER SCIENCE BV
Citation: Tsang, Shirley W, Keene, Janet, Hope, Tony, Spence, Ian, Francis, Paul T, Wong, Peter T-H, Chen, Christopher P, Lai, Mitchell K (2010-01-15). A serotoninergic basis for hyperphagic eating changes in Alzheimer's disease. JOURNAL OF THE NEUROLOGICAL SCIENCES 288 (1-Feb) : 151-155. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2009.08.066
Abstract: Hyperphagia and associated eating changes occur frequently in Alzheimer's disease (AD) and lead to considerable morbidity. However, the neurochemical basis for these neuropsychiatric behaviours is at present unclear. In this study, we measured serotonin transporters, 5-HT1A, 5-HT2A, and 5-HT4 receptors using radioligand binding assays in the postmortem temporal cortex of a cohort of controls and AD patients longitudinally assessed for hyperphagia. We found significant decreases in 5-HT4 receptor densities in the hyperphagic, but not normophagic, AD group. Our data suggest that 5-HT4 receptor deficits may be a specific neurochemical correlate of hyperphagia, and point to the potential pharmacotherapeutic utility of 5-HT4 agonists for these behaviours in AD. © 2009 Elsevier B.V. All rights reserved.
Source Title: JOURNAL OF THE NEUROLOGICAL SCIENCES
URI: https://scholarbank.nus.edu.sg/handle/10635/188384
ISSN: 0022510X
18785883
DOI: 10.1016/j.jns.2009.08.066
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