Please use this identifier to cite or link to this item: https://doi.org/10.3233/JAD-2008-14104
Title: Involvement of an altered 5-HT6 receptor function in behavioral symptoms of Alzheimer's disease
Authors: Marcos, Beatriz
Garcia-Alloza, Monica
Gil-Bea, Francisco J
Chuang, Tsu T
Francis, Paul T
Chen, Christopher P 
Tsang, Shirley WTY 
Lai, Mitchell KP 
Ramirez, Maria J
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
adenylate cyclase
gender
neocortex
psychosis
CENTRAL-NERVOUS-SYSTEM
RAT-BRAIN
MESSENGER-RNA
MEMORY CONSOLIDATION
SEROTONIN RECEPTOR
LOCALIZATION
CLOZAPINE
DEMENTIA
SCHIZOPHRENIA
POSTMORTEM
Issue Date: 1-Jan-2008
Publisher: IOS PRESS
Citation: Marcos, Beatriz, Garcia-Alloza, Monica, Gil-Bea, Francisco J, Chuang, Tsu T, Francis, Paul T, Chen, Christopher P, Tsang, Shirley WTY, Lai, Mitchell KP, Ramirez, Maria J (2008-01-01). Involvement of an altered 5-HT6 receptor function in behavioral symptoms of Alzheimer's disease. JOURNAL OF ALZHEIMERS DISEASE 14 (1) : 43-50. ScholarBank@NUS Repository. https://doi.org/10.3233/JAD-2008-14104
Abstract: We studied the hypothesis that disturbances in 5-HT receptor function in the temporal cortex may contribute to clinical symptoms of Alzheimer's disease (AD). 5-HT density and 5-HT levels were significantly decreased in a cohort of AD patients prospectively assessed for cognitive/behavioral symptoms. cAMP formation after stimulation with the selective 5-HT receptor agonist E-6801 was significantly lower (p<0.01) in AD (170.02 ± 27.53 pmol/mg prot.) compared to controls (823.33 ±196.67). In addition, the ratio cAMP formation after stimulation with E-6801/5-HT receptor density was significantly lower (p< 0.01) in AD (6.67 ± 0.83) compared to controls (16.67 ± 3.33). Splitting these results by sex, 5-HT receptor activation was significantly lower (p<0.01) in AD females compared to males (121.67 ± 30.02 vs. 231.67 ± 34.17 pmol/mg prot). 5-HT density and 5-HT levels were significantly correlated (p≤0.01) in both controls and AD patients, although in AD, this correlation was lost in females. Psychosis factor was the best predictor of reduced 5-HT levels or adenylate cyclase activity after E-6801 stimulation, the former result being due to females. It may be suggested that psychotic symptoms may be related to a dysregulation of 5-HT activation by 5-HT in the temporal cortex. These results are discussed in terms of purported influence of sex and therapeutical approaches to psychosis in AD. © 2008 - IOS Press and the authors. All rights reserved.
Source Title: JOURNAL OF ALZHEIMERS DISEASE
URI: https://scholarbank.nus.edu.sg/handle/10635/188375
ISSN: 13872877
18758908
DOI: 10.3233/JAD-2008-14104
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