Please use this identifier to cite or link to this item: https://doi.org/10.1002/mgg3.313
Title: Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing
Authors: Chew, W.H.W
Courtney, E
Lim, K.H
Li, S.T
Chen, Y
Tan, M.H
Chung, A
Khoo, J
Loh, A 
Soh, S.Y 
Iyer, P 
Loh, L.M
Ngeow, J 
Issue Date: 2017
Publisher: Wiley Blackwell
Citation: Chew, W.H.W, Courtney, E, Lim, K.H, Li, S.T, Chen, Y, Tan, M.H, Chung, A, Khoo, J, Loh, A, Soh, S.Y, Iyer, P, Loh, L.M, Ngeow, J (2017). Clinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing. Molecular Genetics and Genomic Medicine 5 (5) : 602-607. ScholarBank@NUS Repository. https://doi.org/10.1002/mgg3.313
Rights: Attribution 4.0 International
Abstract: Background: Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors of the adrenal glands and paraganglia, occurring sporadically or as a range of hereditary tumor syndromes. About 30% of PPGLs are attributed to germline mutations. Clinical presentation, including localization, malignant potential, and age of onset, varies depending on the genetic background. Genetic testing for PPGLs is not well studied in Southeast Asia. We reviewed clinical management of PPGLs in Singapore, highlighting current gaps in clinical practice. Methods: Medical records of patients with PPGLs between 2005 and 2016 were reviewed. Diagnosis was confirmed histologically and stratified into sporadic or familial/syndromic (FS). Results: Twenty-seven (21.8%) patients were referred to the Cancer Genetics Service (CGS). FS PPGLs (18.5%) and extra-adrenal PPGLs (58.1%) incidences were higher than previous studies. Referrals were lower for sporadic PPGLs compared to FS PPGLs (3.7% vs. 100%). Referrals were highest at diagnosis age <20 years old (80%) and decreased with increasing age; ?20–<40 years old (32.1%), ?40–<60 years old (10.6%). Genetic testing was taken up in 12/27 (44.4%) patients of which 7/12 (58.3%, 3 SDHB, 2 SDHD, 2 VHL) had germline mutations. Conclusion: Opportunities for genetic testing are frequently missed due to low referral rates in patients with apparently sporadic PPGLs, particularly between ages 20-60. © 2017 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.
Source Title: Molecular Genetics and Genomic Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/183555
ISSN: 2324-9269
DOI: 10.1002/mgg3.313
Rights: Attribution 4.0 International
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