Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms18112295
Title: Inter-species host gene expression differences in response to human and avian influenza a virus strains
Authors: Taye, B
Yeo, D
Lee, R.T.C
Tan, B.H
Sugrue, R.J
Maurer-Stroh, S 
Keywords: COP9 signalosome
oxysterol binding protein like 1A
peptides and proteins
Rho guanine nucleotide binding protein
unclassified drug
transcriptome
animal cell
apoptosis
Article
avian influenza virus
Canis
cell proliferation
chicken
down regulation
gene expression
human
human cell
immune response
metabolism
microarray analysis
molecular genetics
nonhuman
principal component analysis
species comparison
upregulation
virus infection
virus isolation
animal
avian influenza
cell line
dog
gene expression regulation
genetics
host pathogen interaction
influenza
Influenza A virus
Influenza A virus (H1N1)
Influenza A virus (H5N2)
Influenza A virus (H9N2)
orthomyxovirus infection
physiology
species difference
virology
Animals
Apoptosis
Cell Line
Chickens
Dogs
Gene Expression Regulation
Host-Pathogen Interactions
Humans
Influenza A virus
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H5N2 Subtype
Influenza A Virus, H9N2 Subtype
Influenza in Birds
Influenza, Human
Metabolic Networks and Pathways
Orthomyxoviridae Infections
Species Specificity
Transcriptome
Issue Date: 2017
Publisher: MDPI
Citation: Taye, B, Yeo, D, Lee, R.T.C, Tan, B.H, Sugrue, R.J, Maurer-Stroh, S (2017). Inter-species host gene expression differences in response to human and avian influenza a virus strains. International Journal of Molecular Sciences 18 (11) : 2295. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18112295
Rights: Attribution 4.0 International
Abstract: Low pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways. The annotations are made available to the community for commonly used microarray chips. We observe a strong tendency of the response being cell type-rather than virus-specific. In chicken cells, we found up-regulation of host factors inducing virus infectivity (e.g., oxysterol binding protein like 1A (OSBPL1A) and Rho GTPase activating protein 21 (ARHGAP21)) while reducing apoptosis (e.g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2)). On the other hand, increased antiviral, pro-apoptotic and inflammatory signatures have been identified in human cells while cell cycle and metabolic pathways were down-regulated. This signature describes how low pathogenic avian influenza (LPAI) viruses are being tolerated and shed from chicken but potentially causing cellular disruption in mammalian cells. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/183492
ISSN: 1661-6596
DOI: 10.3390/ijms18112295
Rights: Attribution 4.0 International
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