Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms18112295
DC FieldValue
dc.titleInter-species host gene expression differences in response to human and avian influenza a virus strains
dc.contributor.authorTaye, B
dc.contributor.authorYeo, D
dc.contributor.authorLee, R.T.C
dc.contributor.authorTan, B.H
dc.contributor.authorSugrue, R.J
dc.contributor.authorMaurer-Stroh, S
dc.date.accessioned2020-11-17T04:36:56Z
dc.date.available2020-11-17T04:36:56Z
dc.date.issued2017
dc.identifier.citationTaye, B, Yeo, D, Lee, R.T.C, Tan, B.H, Sugrue, R.J, Maurer-Stroh, S (2017). Inter-species host gene expression differences in response to human and avian influenza a virus strains. International Journal of Molecular Sciences 18 (11) : 2295. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18112295
dc.identifier.issn1661-6596
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183492
dc.description.abstractLow pathogenic avian influenza (LPAI) viruses are a source of sporadic human infections and could also contribute to future pandemic outbreaks but little is known about inter-species differences in the host responses to these viruses. Here, we studied host gene expression signatures of cell lines from three species (human, chicken, and canine) in response to six different viruses (H1N1/WSN, H5N2/F59, H5N2/F118, H5N2/F189, H5N3 and H9N2). Comprehensive microarray probe set re-annotation and ortholog mapping of the host genes was necessary to allow comparison over extended functionally annotated gene sets and orthologous pathways. The annotations are made available to the community for commonly used microarray chips. We observe a strong tendency of the response being cell type-rather than virus-specific. In chicken cells, we found up-regulation of host factors inducing virus infectivity (e.g., oxysterol binding protein like 1A (OSBPL1A) and Rho GTPase activating protein 21 (ARHGAP21)) while reducing apoptosis (e.g., mitochondrial ribosomal protein S27 (MRPS27)) and increasing cell proliferation (e.g., COP9 signalosome subunit 2 (COPS2)). On the other hand, increased antiviral, pro-apoptotic and inflammatory signatures have been identified in human cells while cell cycle and metabolic pathways were down-regulated. This signature describes how low pathogenic avian influenza (LPAI) viruses are being tolerated and shed from chicken but potentially causing cellular disruption in mammalian cells. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
dc.publisherMDPI
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectCOP9 signalosome
dc.subjectoxysterol binding protein like 1A
dc.subjectpeptides and proteins
dc.subjectRho guanine nucleotide binding protein
dc.subjectunclassified drug
dc.subjecttranscriptome
dc.subjectanimal cell
dc.subjectapoptosis
dc.subjectArticle
dc.subjectavian influenza virus
dc.subjectCanis
dc.subjectcell proliferation
dc.subjectchicken
dc.subjectdown regulation
dc.subjectgene expression
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmune response
dc.subjectmetabolism
dc.subjectmicroarray analysis
dc.subjectmolecular genetics
dc.subjectnonhuman
dc.subjectprincipal component analysis
dc.subjectspecies comparison
dc.subjectupregulation
dc.subjectvirus infection
dc.subjectvirus isolation
dc.subjectanimal
dc.subjectavian influenza
dc.subjectcell line
dc.subjectdog
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjecthost pathogen interaction
dc.subjectinfluenza
dc.subjectInfluenza A virus
dc.subjectInfluenza A virus (H1N1)
dc.subjectInfluenza A virus (H5N2)
dc.subjectInfluenza A virus (H9N2)
dc.subjectorthomyxovirus infection
dc.subjectphysiology
dc.subjectspecies difference
dc.subjectvirology
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectCell Line
dc.subjectChickens
dc.subjectDogs
dc.subjectGene Expression Regulation
dc.subjectHost-Pathogen Interactions
dc.subjectHumans
dc.subjectInfluenza A virus
dc.subjectInfluenza A Virus, H1N1 Subtype
dc.subjectInfluenza A Virus, H5N2 Subtype
dc.subjectInfluenza A Virus, H9N2 Subtype
dc.subjectInfluenza in Birds
dc.subjectInfluenza, Human
dc.subjectMetabolic Networks and Pathways
dc.subjectOrthomyxoviridae Infections
dc.subjectSpecies Specificity
dc.subjectTranscriptome
dc.typeArticle
dc.contributor.departmentDEPT OF BIOLOGICAL SCIENCES
dc.description.doi10.3390/ijms18112295
dc.description.sourcetitleInternational Journal of Molecular Sciences
dc.description.volume18
dc.description.issue11
dc.description.page2295
dc.published.statePublished
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_ijms18112295.pdf2.39 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

2
checked on Apr 15, 2021

Page view(s)

41
checked on Apr 15, 2021

Download(s)

1
checked on Apr 15, 2021

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons