Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom2040524
Title: Functional aspects of PARP1 in DNA repair and transcription
Authors: Ko, H.L
Ren, E.C 
Keywords: ATM protein
ATR protein
BRCA1 protein
BRCA2 protein
E1A associated p300 protein
mitogen activated protein kinase 1
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1
XRCC1 protein
acetylation
adenosine diphosphate ribosylation
cell death
chromatin structure
DNA damage
DNA end joining repair
DNA repair
DNA transcription
excision repair
gene expression
human
inflammation
nonhuman
protein localization
protein phosphorylation
recombination repair
review
sumoylation
transcription regulation
virus replication
Issue Date: 2012
Citation: Ko, H.L, Ren, E.C (2012). Functional aspects of PARP1 in DNA repair and transcription. Biomolecules 2 (4) : 524-548. ScholarBank@NUS Repository. https://doi.org/10.3390/biom2040524
Rights: Attribution 4.0 International
Abstract: Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the treatment of cancers. Through enzyme-dependent chromatin remodeling and enzyme-independent motif recognition, PARP1 also plays important roles in regulating gene expression. Besides presenting current findings on how each process is individually controlled by PARP1, we shall discuss how transcription and DNA repair are so intricately linked that disturbance by PARP1 enzymatic inhibition, enzyme hyperactivation in diseases, and viral replication can favor one function while suppressing the other. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: Biomolecules
URI: https://scholarbank.nus.edu.sg/handle/10635/183240
ISSN: 2218273X
DOI: 10.3390/biom2040524
Rights: Attribution 4.0 International
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