Please use this identifier to cite or link to this item: https://doi.org/10.3390/biom2040524
DC FieldValue
dc.titleFunctional aspects of PARP1 in DNA repair and transcription
dc.contributor.authorKo, H.L
dc.contributor.authorRen, E.C
dc.date.accessioned2020-11-10T00:37:44Z
dc.date.available2020-11-10T00:37:44Z
dc.date.issued2012
dc.identifier.citationKo, H.L, Ren, E.C (2012). Functional aspects of PARP1 in DNA repair and transcription. Biomolecules 2 (4) : 524-548. ScholarBank@NUS Repository. https://doi.org/10.3390/biom2040524
dc.identifier.issn2218273X
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/183240
dc.description.abstractPoly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the treatment of cancers. Through enzyme-dependent chromatin remodeling and enzyme-independent motif recognition, PARP1 also plays important roles in regulating gene expression. Besides presenting current findings on how each process is individually controlled by PARP1, we shall discuss how transcription and DNA repair are so intricately linked that disturbance by PARP1 enzymatic inhibition, enzyme hyperactivation in diseases, and viral replication can favor one function while suppressing the other. © 2011 by the authors; licensee MDPI, Basel, Switzerland.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectATM protein
dc.subjectATR protein
dc.subjectBRCA1 protein
dc.subjectBRCA2 protein
dc.subjectE1A associated p300 protein
dc.subjectmitogen activated protein kinase 1
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1
dc.subjectXRCC1 protein
dc.subjectacetylation
dc.subjectadenosine diphosphate ribosylation
dc.subjectcell death
dc.subjectchromatin structure
dc.subjectDNA damage
dc.subjectDNA end joining repair
dc.subjectDNA repair
dc.subjectDNA transcription
dc.subjectexcision repair
dc.subjectgene expression
dc.subjecthuman
dc.subjectinflammation
dc.subjectnonhuman
dc.subjectprotein localization
dc.subjectprotein phosphorylation
dc.subjectrecombination repair
dc.subjectreview
dc.subjectsumoylation
dc.subjecttranscription regulation
dc.subjectvirus replication
dc.typeReview
dc.contributor.departmentDEPT OF MICROBIOLOGY & IMMUNOLOGY
dc.description.doi10.3390/biom2040524
dc.description.sourcetitleBiomolecules
dc.description.volume2
dc.description.issue4
dc.description.page524-548
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_3390_biom2040524.pdf594.32 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons