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Title: Resveratrol induces insulin gene expression in mouse pancreatic ?-cells
Authors: Xie, S 
Sinha, R.A 
Singh, B.K 
Li, G.D 
Han, W 
Yen, P.M 
Issue Date: 2013
Citation: Xie, S, Sinha, R.A, Singh, B.K, Li, G.D, Han, W, Yen, P.M (2013). Resveratrol induces insulin gene expression in mouse pancreatic ?-cells. Cell and Bioscience 3 (1) : 47. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Type 1 and type 2 diabetes are characterized by loss of ?-cells; therefore, ?-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic compound, has been shown to improve glycaemic control in diabetic patients, but its action on pancreatic ?-cells is not well understood.Findings: Using mouse ?-cells (?TC9), we showed that resveratrol induces expression of pancreatic ?-cell genes such as Pdx1 and Ins2 in a SirT1-dependent manner. The mRNA and protein levels of insulin were further increased by histone deacetylase (HDAC) inhibition.Conclusion: In summary, we provide new mechanistic insight into the anti-diabetic action of resveratrol through its ability to express ?-cell genes in ?-cells. © 2013 Xie et al.; licensee BioMed Central Ltd.
Source Title: Cell and Bioscience
ISSN: 20453701
DOI: 10.1186/2045-3701-3-47
Rights: Attribution 4.0 International
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