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https://doi.org/10.1186/2045-3701-3-47
| DC Field | Value | |
|---|---|---|
| dc.title | Resveratrol induces insulin gene expression in mouse pancreatic ?-cells | |
| dc.contributor.author | Xie, S | |
| dc.contributor.author | Sinha, R.A | |
| dc.contributor.author | Singh, B.K | |
| dc.contributor.author | Li, G.D | |
| dc.contributor.author | Han, W | |
| dc.contributor.author | Yen, P.M | |
| dc.date.accessioned | 2020-10-30T01:59:48Z | |
| dc.date.available | 2020-10-30T01:59:48Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | Xie, S, Sinha, R.A, Singh, B.K, Li, G.D, Han, W, Yen, P.M (2013). Resveratrol induces insulin gene expression in mouse pancreatic ?-cells. Cell and Bioscience 3 (1) : 47. ScholarBank@NUS Repository. https://doi.org/10.1186/2045-3701-3-47 | |
| dc.identifier.issn | 20453701 | |
| dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/182045 | |
| dc.description.abstract | Background: Type 1 and type 2 diabetes are characterized by loss of ?-cells; therefore, ?-cell regeneration has become one of the primary approaches to diabetes therapy. Resveratrol, a naturally occurring polyphenolic compound, has been shown to improve glycaemic control in diabetic patients, but its action on pancreatic ?-cells is not well understood.Findings: Using mouse ?-cells (?TC9), we showed that resveratrol induces expression of pancreatic ?-cell genes such as Pdx1 and Ins2 in a SirT1-dependent manner. The mRNA and protein levels of insulin were further increased by histone deacetylase (HDAC) inhibition.Conclusion: In summary, we provide new mechanistic insight into the anti-diabetic action of resveratrol through its ability to express ?-cell genes in ?-cells. © 2013 Xie et al.; licensee BioMed Central Ltd. | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.source | Unpaywall 20201031 | |
| dc.type | Article | |
| dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
| dc.contributor.department | ANATOMY | |
| dc.description.doi | 10.1186/2045-3701-3-47 | |
| dc.description.sourcetitle | Cell and Bioscience | |
| dc.description.volume | 3 | |
| dc.description.issue | 1 | |
| dc.description.page | 47 | |
| Appears in Collections: | Elements Staff Publications | |
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