Please use this identifier to cite or link to this item: https://doi.org/10.1186/1475-2875-10-23
Title: The relevance of non-human primate and rodent malaria models for humans
Authors: Langhorne, J
Buffet, P
Galinski, M
Good, M
Harty, J
Leroy, D
Mota, M.M
Pasini, E
Renia, L 
Riley, E
Stins, M
Duffy, P
Keywords: antimalarial agent
animal experiment
animal model
controlled study
funding
host parasite interaction
malaria
medical research
nonhuman
note
Plasmodium berghei
Plasmodium falciparum
primate
publication
rat
animal
article
disease model
human
immunology
innate immunity
malaria
mouse
parasitology
physiology
Plasmodium
primate
Animal Experimentation
Animals
Disease Models, Animal
Humans
Immunity, Innate
Malaria
Mice
Plasmodium
Primates
Issue Date: 2011
Citation: Langhorne, J, Buffet, P, Galinski, M, Good, M, Harty, J, Leroy, D, Mota, M.M, Pasini, E, Renia, L, Riley, E, Stins, M, Duffy, P (2011). The relevance of non-human primate and rodent malaria models for humans. Malaria Journal 10 : 23. ScholarBank@NUS Repository. https://doi.org/10.1186/1475-2875-10-23
Rights: Attribution 4.0 International
Abstract: At the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material. © 2011 Langhorne et al; licensee BioMed Central Ltd.
Source Title: Malaria Journal
URI: https://scholarbank.nus.edu.sg/handle/10635/181645
ISSN: 14752875
DOI: 10.1186/1475-2875-10-23
Rights: Attribution 4.0 International
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