Please use this identifier to cite or link to this item: https://doi.org/10.1186/1475-2875-10-23
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dc.titleThe relevance of non-human primate and rodent malaria models for humans
dc.contributor.authorLanghorne, J
dc.contributor.authorBuffet, P
dc.contributor.authorGalinski, M
dc.contributor.authorGood, M
dc.contributor.authorHarty, J
dc.contributor.authorLeroy, D
dc.contributor.authorMota, M.M
dc.contributor.authorPasini, E
dc.contributor.authorRenia, L
dc.contributor.authorRiley, E
dc.contributor.authorStins, M
dc.contributor.authorDuffy, P
dc.date.accessioned2020-10-27T11:34:37Z
dc.date.available2020-10-27T11:34:37Z
dc.date.issued2011
dc.identifier.citationLanghorne, J, Buffet, P, Galinski, M, Good, M, Harty, J, Leroy, D, Mota, M.M, Pasini, E, Renia, L, Riley, E, Stins, M, Duffy, P (2011). The relevance of non-human primate and rodent malaria models for humans. Malaria Journal 10 : 23. ScholarBank@NUS Repository. https://doi.org/10.1186/1475-2875-10-23
dc.identifier.issn14752875
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181645
dc.description.abstractAt the 2010 Keystone Symposium on "Malaria: new approaches to understanding Host-Parasite interactions", an extra scientific session to discuss animal models in malaria research was convened at the request of participants. This was prompted by the concern of investigators that skepticism in the malaria community about the use and relevance of animal models, particularly rodent models of severe malaria, has impacted on funding decisions and publication of research using animal models. Several speakers took the opportunity to demonstrate the similarities between findings in rodent models and human severe disease, as well as points of difference. The variety of malaria presentations in the different experimental models parallels the wide diversity of human malaria disease and, therefore, might be viewed as a strength. Many of the key features of human malaria can be replicated in a variety of nonhuman primate models, which are very under-utilized. The importance of animal models in the discovery of new anti-malarial drugs was emphasized. The major conclusions of the session were that experimental and human studies should be more closely linked so that they inform each other, and that there should be wider access to relevant clinical material. © 2011 Langhorne et al; licensee BioMed Central Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectantimalarial agent
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectfunding
dc.subjecthost parasite interaction
dc.subjectmalaria
dc.subjectmedical research
dc.subjectnonhuman
dc.subjectnote
dc.subjectPlasmodium berghei
dc.subjectPlasmodium falciparum
dc.subjectprimate
dc.subjectpublication
dc.subjectrat
dc.subjectanimal
dc.subjectarticle
dc.subjectdisease model
dc.subjecthuman
dc.subjectimmunology
dc.subjectinnate immunity
dc.subjectmalaria
dc.subjectmouse
dc.subjectparasitology
dc.subjectphysiology
dc.subjectPlasmodium
dc.subjectprimate
dc.subjectAnimal Experimentation
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectMalaria
dc.subjectMice
dc.subjectPlasmodium
dc.subjectPrimates
dc.typeNote
dc.contributor.departmentMICROBIOLOGY AND IMMUNOLOGY
dc.description.doi10.1186/1475-2875-10-23
dc.description.sourcetitleMalaria Journal
dc.description.volume10
dc.description.page23
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