Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2334-11-212
Title: Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome? - A prospective cohort study
Authors: Vasanwala, F.F 
Puvanendran, R 
Fook-Chong, S
Ng, J 
Suhail, S.M 
Lee, K 
Keywords: creatinine
protein
creatinine
adult
analytical parameters
article
clinical article
cohort analysis
controlled study
dengue
dengue shock syndrome
disease classification
disease marker
hospital admission
hospital discharge
human
onset age
prospective study
proteinuria
urine protein creatinine ratio
chemistry
evaluation
middle aged
prognosis
proteinuria
urine
Adult
Cohort Studies
Creatinine
Dengue Hemorrhagic Fever
Humans
Middle Aged
Prognosis
Prospective Studies
Proteinuria
Urine
Issue Date: 2011
Citation: Vasanwala, F.F, Puvanendran, R, Fook-Chong, S, Ng, J, Suhail, S.M, Lee, K (2011). Could peak proteinuria determine whether patient with dengue fever develop dengue hemorrhagic/dengue shock syndrome? - A prospective cohort study. BMC Infectious Diseases 11 : 212. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2334-11-212
Rights: Attribution 4.0 International
Abstract: Background: Worldwide there is a need to develop simple effective predictors that can distinguish whether a patient will progress from dengue fever (DF) to life threatening dengue hemorrhagic (DHF) or dengue shock syndrome (DSS). We explored whether proteinuria could be used as such a marker.Methods: We included patients admitted to hospital with suspected dengue fever. Starting at enrollment until discharge, each patient's daily spot urine protein creatinine ratio (UPCR) was measured. We classified those with confirmed dengue infection as DF or DHF (including DSS) based on WHO criteria. Peak and day of onset of proteinuria was compared between both groups.Results: Compared to those with DF, patients with DHF had significantly higher median peak proteinuria levels (0.56 versus 0.08 g/day; p < 0.001). For patients with DHF, the median day of onset of proteinuria was at 6 days of defervescence, with a range of -2 to +3 days after defervescence. There were three patients with DF who did not have proteinuria during their illness; the five remaining patients with DF had a median day of onset of proteinuria of was at 6 days of defervescence with a range of 0 to +28 days.Conclusions: Peak UPCR could potentially predict DHF in patients with dengue requiring close monitoring and treatment. © 2011 Vasanwala et al; licensee BioMed Central Ltd.
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181629
ISSN: 14712334
DOI: 10.1186/1471-2334-11-212
Rights: Attribution 4.0 International
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