Please use this identifier to cite or link to this item: https://doi.org/10.3390/md12010036
Title: Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis
Authors: Mencarelli, A 
D'Amore, C
Renga, B
Cipriani, S
Carino, A
Sepe, V
Perissutti, E
D'Auria, M.V
Zampella, A
Distrutti, E
Fiorucci, S
Keywords: C reactive protein
cell nucleus receptor
chemokine
collagen antibody
cytokine
gamma interferon
interleukin 10
interleukin 17
macrophage inflammatory protein 1alpha
pregnane derivative
pregnane X receptor
RANTES
solomonsterol A
tumor necrosis factor alpha
unclassified drug
adaptive immunity
animal experiment
animal model
antiinflammatory activity
article
controlled study
histopathology
immunopathology
inflammation
innate immunity
lymph node
male
mouse
nonhuman
rheumatoid arthritis
scoring system
sponge (Porifera)
Theonella swinhoei
Animals
Anti-Inflammatory Agents
Arthritis, Rheumatoid
C-Reactive Protein
Cartilage
Chemokine CCL3
Chemokine CCL5
Cholanes
Collagen Type II
Cytokines
Hepatocytes
Humans
Immunologic Deficiency Syndromes
Interferon-gamma
Interleukin-17
Liver
Lymph Nodes
Mice, Inbred C57BL
Mice, Transgenic
Models, Molecular
Molecular Conformation
Porifera
Receptors, Steroid
Sulfuric Acid Esters
Transcriptional Activation
Tumor Necrosis Factor-alpha
Issue Date: 2014
Citation: Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S (2014). Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis. Marine Drugs 12 (1) : 36-53. ScholarBank@NUS Repository. https://doi.org/10.3390/md12010036
Rights: Attribution 4.0 International
Abstract: In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists. © 2013 by the authors; licensee MDPI.
Source Title: Marine Drugs
URI: https://scholarbank.nus.edu.sg/handle/10635/181535
ISSN: 16603397
DOI: 10.3390/md12010036
Rights: Attribution 4.0 International
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