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https://doi.org/10.3390/md12010036
Title: | Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis | Authors: | Mencarelli, A D'Amore, C Renga, B Cipriani, S Carino, A Sepe, V Perissutti, E D'Auria, M.V Zampella, A Distrutti, E Fiorucci, S |
Keywords: | C reactive protein cell nucleus receptor chemokine collagen antibody cytokine gamma interferon interleukin 10 interleukin 17 macrophage inflammatory protein 1alpha pregnane derivative pregnane X receptor RANTES solomonsterol A tumor necrosis factor alpha unclassified drug adaptive immunity animal experiment animal model antiinflammatory activity article controlled study histopathology immunopathology inflammation innate immunity lymph node male mouse nonhuman rheumatoid arthritis scoring system sponge (Porifera) Theonella swinhoei Animals Anti-Inflammatory Agents Arthritis, Rheumatoid C-Reactive Protein Cartilage Chemokine CCL3 Chemokine CCL5 Cholanes Collagen Type II Cytokines Hepatocytes Humans Immunologic Deficiency Syndromes Interferon-gamma Interleukin-17 Liver Lymph Nodes Mice, Inbred C57BL Mice, Transgenic Models, Molecular Molecular Conformation Porifera Receptors, Steroid Sulfuric Acid Esters Transcriptional Activation Tumor Necrosis Factor-alpha |
Issue Date: | 2014 | Citation: | Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S (2014). Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis. Marine Drugs 12 (1) : 36-53. ScholarBank@NUS Repository. https://doi.org/10.3390/md12010036 | Rights: | Attribution 4.0 International | Abstract: | In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists. © 2013 by the authors; licensee MDPI. | Source Title: | Marine Drugs | URI: | https://scholarbank.nus.edu.sg/handle/10635/181535 | ISSN: | 16603397 | DOI: | 10.3390/md12010036 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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