Please use this identifier to cite or link to this item: https://doi.org/10.3390/md12010036
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dc.titleSolomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis
dc.contributor.authorMencarelli, A
dc.contributor.authorD'Amore, C
dc.contributor.authorRenga, B
dc.contributor.authorCipriani, S
dc.contributor.authorCarino, A
dc.contributor.authorSepe, V
dc.contributor.authorPerissutti, E
dc.contributor.authorD'Auria, M.V
dc.contributor.authorZampella, A
dc.contributor.authorDistrutti, E
dc.contributor.authorFiorucci, S
dc.date.accessioned2020-10-27T11:13:47Z
dc.date.available2020-10-27T11:13:47Z
dc.date.issued2014
dc.identifier.citationMencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S (2014). Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis. Marine Drugs 12 (1) : 36-53. ScholarBank@NUS Repository. https://doi.org/10.3390/md12010036
dc.identifier.issn16603397
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181535
dc.description.abstractIn the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists. © 2013 by the authors; licensee MDPI.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectC reactive protein
dc.subjectcell nucleus receptor
dc.subjectchemokine
dc.subjectcollagen antibody
dc.subjectcytokine
dc.subjectgamma interferon
dc.subjectinterleukin 10
dc.subjectinterleukin 17
dc.subjectmacrophage inflammatory protein 1alpha
dc.subjectpregnane derivative
dc.subjectpregnane X receptor
dc.subjectRANTES
dc.subjectsolomonsterol A
dc.subjecttumor necrosis factor alpha
dc.subjectunclassified drug
dc.subjectadaptive immunity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantiinflammatory activity
dc.subjectarticle
dc.subjectcontrolled study
dc.subjecthistopathology
dc.subjectimmunopathology
dc.subjectinflammation
dc.subjectinnate immunity
dc.subjectlymph node
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectrheumatoid arthritis
dc.subjectscoring system
dc.subjectsponge (Porifera)
dc.subjectTheonella swinhoei
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectArthritis, Rheumatoid
dc.subjectC-Reactive Protein
dc.subjectCartilage
dc.subjectChemokine CCL3
dc.subjectChemokine CCL5
dc.subjectCholanes
dc.subjectCollagen Type II
dc.subjectCytokines
dc.subjectHepatocytes
dc.subjectHumans
dc.subjectImmunologic Deficiency Syndromes
dc.subjectInterferon-gamma
dc.subjectInterleukin-17
dc.subjectLiver
dc.subjectLymph Nodes
dc.subjectMice, Inbred C57BL
dc.subjectMice, Transgenic
dc.subjectModels, Molecular
dc.subjectMolecular Conformation
dc.subjectPorifera
dc.subjectReceptors, Steroid
dc.subjectSulfuric Acid Esters
dc.subjectTranscriptional Activation
dc.subjectTumor Necrosis Factor-alpha
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.3390/md12010036
dc.description.sourcetitleMarine Drugs
dc.description.volume12
dc.description.issue1
dc.description.page36-53
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