Please use this identifier to cite or link to this item:
https://doi.org/10.3390/md12010036
DC Field | Value | |
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dc.title | Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis | |
dc.contributor.author | Mencarelli, A | |
dc.contributor.author | D'Amore, C | |
dc.contributor.author | Renga, B | |
dc.contributor.author | Cipriani, S | |
dc.contributor.author | Carino, A | |
dc.contributor.author | Sepe, V | |
dc.contributor.author | Perissutti, E | |
dc.contributor.author | D'Auria, M.V | |
dc.contributor.author | Zampella, A | |
dc.contributor.author | Distrutti, E | |
dc.contributor.author | Fiorucci, S | |
dc.date.accessioned | 2020-10-27T11:13:47Z | |
dc.date.available | 2020-10-27T11:13:47Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Mencarelli, A, D'Amore, C, Renga, B, Cipriani, S, Carino, A, Sepe, V, Perissutti, E, D'Auria, M.V, Zampella, A, Distrutti, E, Fiorucci, S (2014). Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis. Marine Drugs 12 (1) : 36-53. ScholarBank@NUS Repository. https://doi.org/10.3390/md12010036 | |
dc.identifier.issn | 16603397 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181535 | |
dc.description.abstract | In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic inflammation and immune dysfunction in a mouse model of rheumatoid arthritis. Solomonsterol A was effective in protecting against the development of arthritis induced by injecting transgenic mice harboring a humanized PXR, with anti-collagen antibodies (CAIA) with beneficial effects on joint histopathology and local inflammatory response reducing the expression of inflammatory markers (TNFα, IFNγ and IL-17 and chemokines MIP1α and RANTES) in draining lymph nodes. Solomonsterol A rescued mice from systemic inflammation were assessed by measuring arthritis score, CRP and cytokines in the blood. In summary, the present study provides a molecular basis for the regulation of systemic local and systemic immunity by PXR agonists. © 2013 by the authors; licensee MDPI. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | C reactive protein | |
dc.subject | cell nucleus receptor | |
dc.subject | chemokine | |
dc.subject | collagen antibody | |
dc.subject | cytokine | |
dc.subject | gamma interferon | |
dc.subject | interleukin 10 | |
dc.subject | interleukin 17 | |
dc.subject | macrophage inflammatory protein 1alpha | |
dc.subject | pregnane derivative | |
dc.subject | pregnane X receptor | |
dc.subject | RANTES | |
dc.subject | solomonsterol A | |
dc.subject | tumor necrosis factor alpha | |
dc.subject | unclassified drug | |
dc.subject | adaptive immunity | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | antiinflammatory activity | |
dc.subject | article | |
dc.subject | controlled study | |
dc.subject | histopathology | |
dc.subject | immunopathology | |
dc.subject | inflammation | |
dc.subject | innate immunity | |
dc.subject | lymph node | |
dc.subject | male | |
dc.subject | mouse | |
dc.subject | nonhuman | |
dc.subject | rheumatoid arthritis | |
dc.subject | scoring system | |
dc.subject | sponge (Porifera) | |
dc.subject | Theonella swinhoei | |
dc.subject | Animals | |
dc.subject | Anti-Inflammatory Agents | |
dc.subject | Arthritis, Rheumatoid | |
dc.subject | C-Reactive Protein | |
dc.subject | Cartilage | |
dc.subject | Chemokine CCL3 | |
dc.subject | Chemokine CCL5 | |
dc.subject | Cholanes | |
dc.subject | Collagen Type II | |
dc.subject | Cytokines | |
dc.subject | Hepatocytes | |
dc.subject | Humans | |
dc.subject | Immunologic Deficiency Syndromes | |
dc.subject | Interferon-gamma | |
dc.subject | Interleukin-17 | |
dc.subject | Liver | |
dc.subject | Lymph Nodes | |
dc.subject | Mice, Inbred C57BL | |
dc.subject | Mice, Transgenic | |
dc.subject | Models, Molecular | |
dc.subject | Molecular Conformation | |
dc.subject | Porifera | |
dc.subject | Receptors, Steroid | |
dc.subject | Sulfuric Acid Esters | |
dc.subject | Transcriptional Activation | |
dc.subject | Tumor Necrosis Factor-alpha | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.3390/md12010036 | |
dc.description.sourcetitle | Marine Drugs | |
dc.description.volume | 12 | |
dc.description.issue | 1 | |
dc.description.page | 36-53 | |
Appears in Collections: | Elements Staff Publications |
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