Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12883-016-0773-2
Title: Presynaptic neuromuscular transmission defect in the stiff person syndrome
Authors: Lo, Y.L 
Tan, Y.E
Keywords: corticosteroid
immunoglobulin G
pyridostigmine
autoantibody
cholinesterase inhibitor
glutamate decarboxylase
pyridostigmine
adult
Article
backache
brain electrophysiology
case report
chronic fatigue syndrome
disease severity
encephalomyelitis
exercise
fasciculation
female
fibromyalgia
human
male
mental stress
middle aged
motor unit
muscle action potential
muscle atrophy
muscle cramp
muscle rigidity
muscle spasm
nerve conduction
nerve stimulation
neuromuscular transmission
presynaptic potential
stiff man syndrome
treatment response
tremor
blood
complication
fatigue
immunology
neuromuscular junction
physiology
rare disease
Stiff-Person Syndrome
synaptic transmission
Autoantibodies
Cholinesterase Inhibitors
Fatigue
Female
Glutamate Decarboxylase
Humans
Male
Middle Aged
Neuromuscular Junction
Pyridostigmine Bromide
Rare Diseases
Stiff-Person Syndrome
Synaptic Transmission
Issue Date: 2016
Citation: Lo, Y.L, Tan, Y.E (2016). Presynaptic neuromuscular transmission defect in the stiff person syndrome. BMC Neurology 16 (1) : 249. ScholarBank@NUS Repository. https://doi.org/10.1186/s12883-016-0773-2
Rights: Attribution 4.0 International
Abstract: Background: The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. Case presentations: We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms. Conclusions: Our findings suggest that glutamic acid decarboxylase (GAD) antibodies may play a role in presynaptic neuromuscular transmission defect of SPS patients with fatigue. © 2016 The Author(s).
Source Title: BMC Neurology
URI: https://scholarbank.nus.edu.sg/handle/10635/181322
ISSN: 14712377
DOI: 10.1186/s12883-016-0773-2
Rights: Attribution 4.0 International
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