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https://doi.org/10.1186/s12883-016-0773-2
| Title: | Presynaptic neuromuscular transmission defect in the stiff person syndrome | Authors: | Lo, Y.L Tan, Y.E |
Keywords: | corticosteroid immunoglobulin G pyridostigmine autoantibody cholinesterase inhibitor glutamate decarboxylase pyridostigmine adult Article backache brain electrophysiology case report chronic fatigue syndrome disease severity encephalomyelitis exercise fasciculation female fibromyalgia human male mental stress middle aged motor unit muscle action potential muscle atrophy muscle cramp muscle rigidity muscle spasm nerve conduction nerve stimulation neuromuscular transmission presynaptic potential stiff man syndrome treatment response tremor blood complication fatigue immunology neuromuscular junction physiology rare disease Stiff-Person Syndrome synaptic transmission Autoantibodies Cholinesterase Inhibitors Fatigue Female Glutamate Decarboxylase Humans Male Middle Aged Neuromuscular Junction Pyridostigmine Bromide Rare Diseases Stiff-Person Syndrome Synaptic Transmission |
Issue Date: | 2016 | Citation: | Lo, Y.L, Tan, Y.E (2016). Presynaptic neuromuscular transmission defect in the stiff person syndrome. BMC Neurology 16 (1) : 249. ScholarBank@NUS Repository. https://doi.org/10.1186/s12883-016-0773-2 | Rights: | Attribution 4.0 International | Abstract: | Background: The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. Case presentations: We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms. Conclusions: Our findings suggest that glutamic acid decarboxylase (GAD) antibodies may play a role in presynaptic neuromuscular transmission defect of SPS patients with fatigue. © 2016 The Author(s). | Source Title: | BMC Neurology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181322 | ISSN: | 14712377 | DOI: | 10.1186/s12883-016-0773-2 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Elements Staff Publications |
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