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Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12883-016-0773-2
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dc.titlePresynaptic neuromuscular transmission defect in the stiff person syndrome
dc.contributor.authorLo, Y.L
dc.contributor.authorTan, Y.E
dc.date.accessioned2020-10-27T10:34:14Z
dc.date.available2020-10-27T10:34:14Z
dc.date.issued2016
dc.identifier.citationLo, Y.L, Tan, Y.E (2016). Presynaptic neuromuscular transmission defect in the stiff person syndrome. BMC Neurology 16 (1) : 249. ScholarBank@NUS Repository. https://doi.org/10.1186/s12883-016-0773-2
dc.identifier.issn14712377
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181322
dc.description.abstractBackground: The stiff person syndrome (SPS) is a rare disorder characterized by muscular rigidity and stiffness. Case presentations: We describe an SPS patient presenting with longstanding fatigue and electrophysiological evidence of presynaptic neuromuscular transmission defect, who responded to administration of pyridostigmine. In contrast, no electrophysiolgical evidence of neuromuscular transmission defect was demonstrated in 2 other SPS patients without fatigue symptoms. Conclusions: Our findings suggest that glutamic acid decarboxylase (GAD) antibodies may play a role in presynaptic neuromuscular transmission defect of SPS patients with fatigue. © 2016 The Author(s).
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectcorticosteroid
dc.subjectimmunoglobulin G
dc.subjectpyridostigmine
dc.subjectautoantibody
dc.subjectcholinesterase inhibitor
dc.subjectglutamate decarboxylase
dc.subjectpyridostigmine
dc.subjectadult
dc.subjectArticle
dc.subjectbackache
dc.subjectbrain electrophysiology
dc.subjectcase report
dc.subjectchronic fatigue syndrome
dc.subjectdisease severity
dc.subjectencephalomyelitis
dc.subjectexercise
dc.subjectfasciculation
dc.subjectfemale
dc.subjectfibromyalgia
dc.subjecthuman
dc.subjectmale
dc.subjectmental stress
dc.subjectmiddle aged
dc.subjectmotor unit
dc.subjectmuscle action potential
dc.subjectmuscle atrophy
dc.subjectmuscle cramp
dc.subjectmuscle rigidity
dc.subjectmuscle spasm
dc.subjectnerve conduction
dc.subjectnerve stimulation
dc.subjectneuromuscular transmission
dc.subjectpresynaptic potential
dc.subjectstiff man syndrome
dc.subjecttreatment response
dc.subjecttremor
dc.subjectblood
dc.subjectcomplication
dc.subjectfatigue
dc.subjectimmunology
dc.subjectneuromuscular junction
dc.subjectphysiology
dc.subjectrare disease
dc.subjectStiff-Person Syndrome
dc.subjectsynaptic transmission
dc.subjectAutoantibodies
dc.subjectCholinesterase Inhibitors
dc.subjectFatigue
dc.subjectFemale
dc.subjectGlutamate Decarboxylase
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuromuscular Junction
dc.subjectPyridostigmine Bromide
dc.subjectRare Diseases
dc.subjectStiff-Person Syndrome
dc.subjectSynaptic Transmission
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1186/s12883-016-0773-2
dc.description.sourcetitleBMC Neurology
dc.description.volume16
dc.description.issue1
dc.description.page249
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