Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnana.2017.00079
Title: Medial septum modulates cellular response induced in hippocampus on microinjection of cholinergic agonists into hypothalamic lateral supramammillary nucleus
Authors: Ariffin, M.Z 
Low, C.-M 
Khanna, S 
Keywords: carbachol
cholinergic receptor stimulating agent
muscimol
nicotine tartrate
nicotinic receptor
protein c fos
animal cell
animal experiment
animal tissue
Article
brain electrophysiology
brain perfusion
cell nucleus
cingulate gyrus
confocal microscopy
controlled study
dentate gyrus
forebrain tissue
hippocampal CA1 region
hippocampal CA2 region
hippocampal CA3 region
hippocampus
hippocampus theta rhythm
hypothalamus nucleus
immunofluorescence
immunohistochemistry
immunoreactivity
interneuron
lateral supramammillary nucleus
male
medial septal nucleus
microinjection
nonhuman
protein expression
qualitative analysis
quantitative analysis
rat
Issue Date: 2017
Citation: Ariffin, M.Z, Low, C.-M, Khanna, S (2017). Medial septum modulates cellular response induced in hippocampus on microinjection of cholinergic agonists into hypothalamic lateral supramammillary nucleus. Frontiers in Neuroanatomy 11 : 79. ScholarBank@NUS Repository. https://doi.org/10.3389/fnana.2017.00079
Rights: Attribution 4.0 International
Abstract: Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we have investigated whether the effects of cholinergic activation of SuM on hippocampal and cortical neural activities involve a cooperative interaction with the medial septum (MS). Microinjection of the broadspectrum cholinergic agonist, carbachol, or the cholinergic-nicotinic receptor agonist, nicotine, into the lSuM and the mSuM in urethane anesthetized rat evoked a similar pattern of hippocampal theta rhythm. Despite that, only the lSuM microinjections resulted in an increase in expression of c-Fos-like immunoreactivity (c-Fos-ir) in neurons, including interneurons, of the ipsilateral hippocampus with a very dense expression in dentate gyrus. Likewise, a robust induction of c-Fos-ir was also observed in the ipsilateral Cg. Inhibition of the MS with muscimol pre-treatment attenuated both carbachol-evoked c-Fos-ir and theta activation. The findings indicate that cholinergic-nicotinic mechanisms in lSuM evoke not only neural activation via the ascending synchronizing pathway but also an MS-modulated expression of the plasticity-related molecule c-Fos in cortical regions that are strongly innervated by the lSuM. © 2017 Ariffin, Low and Khanna.
Source Title: Frontiers in Neuroanatomy
URI: https://scholarbank.nus.edu.sg/handle/10635/181248
ISSN: 16625129
DOI: 10.3389/fnana.2017.00079
Rights: Attribution 4.0 International
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