Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnana.2017.00079
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dc.titleMedial septum modulates cellular response induced in hippocampus on microinjection of cholinergic agonists into hypothalamic lateral supramammillary nucleus
dc.contributor.authorAriffin, M.Z
dc.contributor.authorLow, C.-M
dc.contributor.authorKhanna, S
dc.date.accessioned2020-10-27T10:20:38Z
dc.date.available2020-10-27T10:20:38Z
dc.date.issued2017
dc.identifier.citationAriffin, M.Z, Low, C.-M, Khanna, S (2017). Medial septum modulates cellular response induced in hippocampus on microinjection of cholinergic agonists into hypothalamic lateral supramammillary nucleus. Frontiers in Neuroanatomy 11 : 79. ScholarBank@NUS Repository. https://doi.org/10.3389/fnana.2017.00079
dc.identifier.issn16625129
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181248
dc.description.abstractCholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and cingulate cortex (Cg). In the present study, we have investigated whether the effects of cholinergic activation of SuM on hippocampal and cortical neural activities involve a cooperative interaction with the medial septum (MS). Microinjection of the broadspectrum cholinergic agonist, carbachol, or the cholinergic-nicotinic receptor agonist, nicotine, into the lSuM and the mSuM in urethane anesthetized rat evoked a similar pattern of hippocampal theta rhythm. Despite that, only the lSuM microinjections resulted in an increase in expression of c-Fos-like immunoreactivity (c-Fos-ir) in neurons, including interneurons, of the ipsilateral hippocampus with a very dense expression in dentate gyrus. Likewise, a robust induction of c-Fos-ir was also observed in the ipsilateral Cg. Inhibition of the MS with muscimol pre-treatment attenuated both carbachol-evoked c-Fos-ir and theta activation. The findings indicate that cholinergic-nicotinic mechanisms in lSuM evoke not only neural activation via the ascending synchronizing pathway but also an MS-modulated expression of the plasticity-related molecule c-Fos in cortical regions that are strongly innervated by the lSuM. © 2017 Ariffin, Low and Khanna.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectcarbachol
dc.subjectcholinergic receptor stimulating agent
dc.subjectmuscimol
dc.subjectnicotine tartrate
dc.subjectnicotinic receptor
dc.subjectprotein c fos
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbrain electrophysiology
dc.subjectbrain perfusion
dc.subjectcell nucleus
dc.subjectcingulate gyrus
dc.subjectconfocal microscopy
dc.subjectcontrolled study
dc.subjectdentate gyrus
dc.subjectforebrain tissue
dc.subjecthippocampal CA1 region
dc.subjecthippocampal CA2 region
dc.subjecthippocampal CA3 region
dc.subjecthippocampus
dc.subjecthippocampus theta rhythm
dc.subjecthypothalamus nucleus
dc.subjectimmunofluorescence
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectinterneuron
dc.subjectlateral supramammillary nucleus
dc.subjectmale
dc.subjectmedial septal nucleus
dc.subjectmicroinjection
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectqualitative analysis
dc.subjectquantitative analysis
dc.subjectrat
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDEPT OF PHARMACOLOGY
dc.description.doi10.3389/fnana.2017.00079
dc.description.sourcetitleFrontiers in Neuroanatomy
dc.description.volume11
dc.description.page79
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