Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12879-017-2793-y
Title: The epidemiology and transmission of methicillin-resistant Staphylococcus aureus in the community in Singapore: Study protocol for a longitudinal household study
Authors: Shankar, N 
Chow, A.L.P 
Oon, J 
Hsu, L.Y 
Ang, B
Pang, J 
De Sessions, P.F
Periaswamy, B
Tambyah, P.A 
Teo, D.B
Tam, C.C 
Keywords: DNA
Article
axilla
bacterial colonization
bacterial transmission
bacterium culture
bacterium detection
contact examination
demography
health care facility
health status
household
human
infection control
inguinal region
longitudinal study
major clinical study
medical history
medical staff
methicillin resistant Staphylococcus aureus
nonhuman
nose smear
prevalence
prospective study
questionnaire
screening test
Singapore
smear
Staphylococcus infection
tertiary care center
validation study
whole genome sequencing
adult
community acquired infection
family size
genetics
isolation and purification
methicillin resistant Staphylococcus aureus
microbiology
nose
Staphylococcus infection
transmission
Adult
Community-Acquired Infections
Family Characteristics
Health Facilities
Humans
Longitudinal Studies
Methicillin-Resistant Staphylococcus aureus
Nose
Prevalence
Prospective Studies
Singapore
Staphylococcal Infections
Surveys and Questionnaires
Tertiary Care Centers
Issue Date: 2017
Citation: Shankar, N, Chow, A.L.P, Oon, J, Hsu, L.Y, Ang, B, Pang, J, De Sessions, P.F, Periaswamy, B, Tambyah, P.A, Teo, D.B, Tam, C.C (2017). The epidemiology and transmission of methicillin-resistant Staphylococcus aureus in the community in Singapore: Study protocol for a longitudinal household study. BMC Infectious Diseases 17 (1) : 678. ScholarBank@NUS Repository. https://doi.org/10.1186/s12879-017-2793-y
Rights: Attribution 4.0 International
Abstract: Background/aim: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common multidrug-resistant organisms in healthcare settings worldwide, but little is known about MRSA transmission outside of acute healthcare settings especially in Asia. We describe the methods for a prospective longitudinal study of MRSA prevalence and transmission. Methods: MRSA-colonized individuals were identified from MRSA admission screening at two tertiary hospitals and recruited together with their household contacts. Participants submitted self-collected nasal, axilla and groin (NAG) swabs by mail for MRSA culture at baseline and monthly thereafter for 6 months. A comparison group of households of MRSA-negative patients provided swab samples at one time point. In a validation sub-study, separate swabs from each site were collected from randomly selected individuals, to compare MRSA detection rates between swab sites, and between samples collected by participants versus those collected by trained research staff. Information on each participant's demographic information, medical status and medical history, past healthcare facilities usage and contacts, and personal interactions with others were collected using a self-administered questionnaire. Discussion/conclusion: Understanding the dynamics of MRSA persistence and transmission in the community is crucial to devising and evaluating successful MRSA control strategies. Close contact with MRSA colonized patients may to be important for MRSA persistence in the community; evidence from this study on the extent of community MRSA could inform the development of household- or community-based interventions to reduce MRSA colonization of close contacts and subsequent re-introduction of MRSA into healthcare settings. Analysis of longitudinal data using whole-genome sequencing will yield further information regarding MRSA transmission within households, with significant implications for MRSA infection control outside acute hospital settings. © 2017 The Author(s).
Source Title: BMC Infectious Diseases
URI: https://scholarbank.nus.edu.sg/handle/10635/181244
ISSN: 14712334
DOI: 10.1186/s12879-017-2793-y
Rights: Attribution 4.0 International
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