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https://doi.org/10.1158/1078-0432.CCR-03-0341
Title: | Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis | Authors: | Sugimura, J Foster, R.S Cummings, O.W Kort, E.J Takahashi, M Lavery, T.T Furge, K.A Einhorn, L.H Teh, B.T |
Keywords: | antineoplastic agent article cancer diagnosis cancer genetics cancer survival cancer therapy clinical article controlled study correlation analysis DNA microarray embryonal carcinoma gene expression profiling histopathology human human tissue lymph node metastasis male malignant transformation molecular mechanics neuroectoderm tumor non seminomatous germinoma nucleotide sequence priority journal prognosis reverse transcription polymerase chain reaction testis teratoma testis tumor tumor growth tumor recurrence unindexed sequence yolk sac tumor Cell Transformation, Neoplastic Chromosome Aberrations DNA, Complementary Gene Expression Regulation, Neoplastic Humans Male Neoplasm Metastasis Neoplasms, Germ Cell and Embryonal Neuroectodermal Tumors, Primitive, Peripheral Oligonucleotide Array Sequence Analysis Prognosis Recurrence Reverse Transcriptase Polymerase Chain Reaction Teratoma Testicular Neoplasms Time Factors |
Issue Date: | 2004 | Citation: | Sugimura, J, Foster, R.S, Cummings, O.W, Kort, E.J, Takahashi, M, Lavery, T.T, Furge, K.A, Einhorn, L.H, Teh, B.T (2004). Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis. Clinical Cancer Research 10 (7) : 2368-2378. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-03-0341 | Rights: | Attribution 4.0 International | Abstract: | Purpose: To better understand the molecular mechanisms that underlay the development and progression of nonseminomatous germ cell tumor of testis (NSGCTT) as well as malignant transformation of teratoma and primitive neuroectodermal tumor (PNET). Experimental Design: We studied the gene expression profiles of 17 retroperitoneal NSGCTTs (10 yolk sac tumors, 3 embryonal carcinomas, 4 teratomas) and 2 PNETs obtained from patients with two clinical outcomes. Tissue samples were obtained from the Indiana University. One group of NSGCTT and PNET patients developed metastases within 2 years (early-relapse) of initial successful treatment, and the other group developed metastases after 2 years (late-relapse). Gene expression in these groups of patients was quantified using cDNA microarrays and real-time relative quantitative PCR. Results: We demonstrate that the gene expression profiles of these tumors correlate with histological type. In addition, we identify type-specific genes that may serve as novel diagnostic markers. We also identify a gene set that can distinguish between early-relapse and late-relapse yolk sac tumors. The expression differences of these genes may underlie the differences in clinical outcome and drug response of these tumors. Conclusion: This is the first study that used gene expression profiling to examine the molecular characteristics of the NSGCTTs and drug response in early- and late-relapse tumors. These results suggest that two molecularly distinct forms of NSGCTTs exist and that the integration of expression profile data with clinical parameters could enhance the diagnosis and prognosis of NSGCTTs. More importantly, the identified genes provide insight into the molecular mechanisms of aggressive NSGCTTs and suggest intervention strategies. | Source Title: | Clinical Cancer Research | URI: | https://scholarbank.nus.edu.sg/handle/10635/181111 | ISSN: | 10780432 | DOI: | 10.1158/1078-0432.CCR-03-0341 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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