Please use this identifier to cite or link to this item: https://doi.org/10.1158/1078-0432.CCR-03-0341
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dc.titleGene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis
dc.contributor.authorSugimura, J
dc.contributor.authorFoster, R.S
dc.contributor.authorCummings, O.W
dc.contributor.authorKort, E.J
dc.contributor.authorTakahashi, M
dc.contributor.authorLavery, T.T
dc.contributor.authorFurge, K.A
dc.contributor.authorEinhorn, L.H
dc.contributor.authorTeh, B.T
dc.date.accessioned2020-10-27T09:52:33Z
dc.date.available2020-10-27T09:52:33Z
dc.date.issued2004
dc.identifier.citationSugimura, J, Foster, R.S, Cummings, O.W, Kort, E.J, Takahashi, M, Lavery, T.T, Furge, K.A, Einhorn, L.H, Teh, B.T (2004). Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis. Clinical Cancer Research 10 (7) : 2368-2378. ScholarBank@NUS Repository. https://doi.org/10.1158/1078-0432.CCR-03-0341
dc.identifier.issn10780432
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/181111
dc.description.abstractPurpose: To better understand the molecular mechanisms that underlay the development and progression of nonseminomatous germ cell tumor of testis (NSGCTT) as well as malignant transformation of teratoma and primitive neuroectodermal tumor (PNET). Experimental Design: We studied the gene expression profiles of 17 retroperitoneal NSGCTTs (10 yolk sac tumors, 3 embryonal carcinomas, 4 teratomas) and 2 PNETs obtained from patients with two clinical outcomes. Tissue samples were obtained from the Indiana University. One group of NSGCTT and PNET patients developed metastases within 2 years (early-relapse) of initial successful treatment, and the other group developed metastases after 2 years (late-relapse). Gene expression in these groups of patients was quantified using cDNA microarrays and real-time relative quantitative PCR. Results: We demonstrate that the gene expression profiles of these tumors correlate with histological type. In addition, we identify type-specific genes that may serve as novel diagnostic markers. We also identify a gene set that can distinguish between early-relapse and late-relapse yolk sac tumors. The expression differences of these genes may underlie the differences in clinical outcome and drug response of these tumors. Conclusion: This is the first study that used gene expression profiling to examine the molecular characteristics of the NSGCTTs and drug response in early- and late-relapse tumors. These results suggest that two molecularly distinct forms of NSGCTTs exist and that the integration of expression profile data with clinical parameters could enhance the diagnosis and prognosis of NSGCTTs. More importantly, the identified genes provide insight into the molecular mechanisms of aggressive NSGCTTs and suggest intervention strategies.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectantineoplastic agent
dc.subjectarticle
dc.subjectcancer diagnosis
dc.subjectcancer genetics
dc.subjectcancer survival
dc.subjectcancer therapy
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectDNA microarray
dc.subjectembryonal carcinoma
dc.subjectgene expression profiling
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectlymph node metastasis
dc.subjectmale
dc.subjectmalignant transformation
dc.subjectmolecular mechanics
dc.subjectneuroectoderm tumor
dc.subjectnon seminomatous germinoma
dc.subjectnucleotide sequence
dc.subjectpriority journal
dc.subjectprognosis
dc.subjectreverse transcription polymerase chain reaction
dc.subjecttestis teratoma
dc.subjecttestis tumor
dc.subjecttumor growth
dc.subjecttumor recurrence
dc.subjectunindexed sequence
dc.subjectyolk sac tumor
dc.subjectCell Transformation, Neoplastic
dc.subjectChromosome Aberrations
dc.subjectDNA, Complementary
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHumans
dc.subjectMale
dc.subjectNeoplasm Metastasis
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectNeuroectodermal Tumors, Primitive, Peripheral
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectPrognosis
dc.subjectRecurrence
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectTeratoma
dc.subjectTesticular Neoplasms
dc.subjectTime Factors
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1158/1078-0432.CCR-03-0341
dc.description.sourcetitleClinical Cancer Research
dc.description.volume10
dc.description.issue7
dc.description.page2368-2378
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