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https://doi.org/10.18632/oncotarget.4729
| Title: | SIRT1 in B[a]P-induced lung tumorigenesis | Authors: | Lu, J Zhang, M Huang, Z Sun, S Zhang, Y Zhang, L Peng, L Ma, A Ji, P Dai, J Cui, T Liu, H Gao, J |
Keywords: | beta catenin sirtuin 1 tumor necrosis factor alpha uvomorulin benzo[a]pyrene beta catenin SIRT1 protein, human sirtuin 1 tumor necrosis factor animal experiment animal model animal tissue Article bronchus mucosa cell invasion cell migration controlled study down regulation epithelium cell human human cell human tissue lung carcinogenesis mouse nonhuman protein expression protein function protein protein interaction protein targeting tumor biopsy upregulation Wnt signaling pathway adverse effects animal biopsy bronchus C57BL mouse carcinogenesis cell motion cell transformation chemically induced chemistry female genetic transcription lung lung tumor metabolism nude mouse pathology smoking tumor cell line tumor invasion Animals Benzo(a)pyrene beta Catenin Biopsy Bronchi Carcinogenesis Cell Line, Tumor Cell Movement Cell Transformation, Neoplastic Epithelial Cells Female Humans Lung Lung Neoplasms Mice Mice, Inbred C57BL Mice, Nude Neoplasm Invasiveness Sirtuin 1 Smoking Transcription, Genetic Tumor Necrosis Factor-alpha Up-Regulation |
Issue Date: | 2015 | Citation: | Lu, J, Zhang, M, Huang, Z, Sun, S, Zhang, Y, Zhang, L, Peng, L, Ma, A, Ji, P, Dai, J, Cui, T, Liu, H, Gao, J (2015). SIRT1 in B[a]P-induced lung tumorigenesis. Oncotarget 6 (29) : 27113-27129. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4729 | Rights: | Attribution 4.0 International | Abstract: | Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]Pinduced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressedin the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1up-regulated TNF-α and β-catenin and down-regulated the membrane fraction ofE-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesisof BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved inB[a]P-induced transformation associated with activation of the TNF-α/β-catenin axisand is as a potential therapeutic target for lung cancer. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/180937 | ISSN: | 19492553 | DOI: | 10.18632/oncotarget.4729 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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