Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.4729
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dc.titleSIRT1 in B[a]P-induced lung tumorigenesis
dc.contributor.authorLu, J
dc.contributor.authorZhang, M
dc.contributor.authorHuang, Z
dc.contributor.authorSun, S
dc.contributor.authorZhang, Y
dc.contributor.authorZhang, L
dc.contributor.authorPeng, L
dc.contributor.authorMa, A
dc.contributor.authorJi, P
dc.contributor.authorDai, J
dc.contributor.authorCui, T
dc.contributor.authorLiu, H
dc.contributor.authorGao, J
dc.date.accessioned2020-10-27T05:47:06Z
dc.date.available2020-10-27T05:47:06Z
dc.date.issued2015
dc.identifier.citationLu, J, Zhang, M, Huang, Z, Sun, S, Zhang, Y, Zhang, L, Peng, L, Ma, A, Ji, P, Dai, J, Cui, T, Liu, H, Gao, J (2015). SIRT1 in B[a]P-induced lung tumorigenesis. Oncotarget 6 (29) : 27113-27129. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4729
dc.identifier.issn19492553
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180937
dc.description.abstractBenzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]Pinduced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressedin the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1up-regulated TNF-α and β-catenin and down-regulated the membrane fraction ofE-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesisof BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved inB[a]P-induced transformation associated with activation of the TNF-α/β-catenin axisand is as a potential therapeutic target for lung cancer.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbeta catenin
dc.subjectsirtuin 1
dc.subjecttumor necrosis factor alpha
dc.subjectuvomorulin
dc.subjectbenzo[a]pyrene
dc.subjectbeta catenin
dc.subjectSIRT1 protein, human
dc.subjectsirtuin 1
dc.subjecttumor necrosis factor
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbronchus mucosa
dc.subjectcell invasion
dc.subjectcell migration
dc.subjectcontrolled study
dc.subjectdown regulation
dc.subjectepithelium cell
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectlung carcinogenesis
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectprotein function
dc.subjectprotein protein interaction
dc.subjectprotein targeting
dc.subjecttumor biopsy
dc.subjectupregulation
dc.subjectWnt signaling pathway
dc.subjectadverse effects
dc.subjectanimal
dc.subjectbiopsy
dc.subjectbronchus
dc.subjectC57BL mouse
dc.subjectcarcinogenesis
dc.subjectcell motion
dc.subjectcell transformation
dc.subjectchemically induced
dc.subjectchemistry
dc.subjectfemale
dc.subjectgenetic transcription
dc.subjectlung
dc.subjectlung tumor
dc.subjectmetabolism
dc.subjectnude mouse
dc.subjectpathology
dc.subjectsmoking
dc.subjecttumor cell line
dc.subjecttumor invasion
dc.subjectAnimals
dc.subjectBenzo(a)pyrene
dc.subjectbeta Catenin
dc.subjectBiopsy
dc.subjectBronchi
dc.subjectCarcinogenesis
dc.subjectCell Line, Tumor
dc.subjectCell Movement
dc.subjectCell Transformation, Neoplastic
dc.subjectEpithelial Cells
dc.subjectFemale
dc.subjectHumans
dc.subjectLung
dc.subjectLung Neoplasms
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectMice, Nude
dc.subjectNeoplasm Invasiveness
dc.subjectSirtuin 1
dc.subjectSmoking
dc.subjectTranscription, Genetic
dc.subjectTumor Necrosis Factor-alpha
dc.subjectUp-Regulation
dc.typeArticle
dc.contributor.departmentDEPT OF COMPUTER SCIENCE
dc.description.doi10.18632/oncotarget.4729
dc.description.sourcetitleOncotarget
dc.description.volume6
dc.description.issue29
dc.description.page27113-27129
dc.published.statePublished
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