Please use this identifier to cite or link to this item: https://doi.org/10.18632/oncotarget.4729
Title: SIRT1 in B[a]P-induced lung tumorigenesis
Authors: Lu, J
Zhang, M
Huang, Z 
Sun, S
Zhang, Y
Zhang, L
Peng, L
Ma, A
Ji, P
Dai, J
Cui, T
Liu, H
Gao, J
Keywords: beta catenin
sirtuin 1
tumor necrosis factor alpha
uvomorulin
benzo[a]pyrene
beta catenin
SIRT1 protein, human
sirtuin 1
tumor necrosis factor
animal experiment
animal model
animal tissue
Article
bronchus mucosa
cell invasion
cell migration
controlled study
down regulation
epithelium cell
human
human cell
human tissue
lung carcinogenesis
mouse
nonhuman
protein expression
protein function
protein protein interaction
protein targeting
tumor biopsy
upregulation
Wnt signaling pathway
adverse effects
animal
biopsy
bronchus
C57BL mouse
carcinogenesis
cell motion
cell transformation
chemically induced
chemistry
female
genetic transcription
lung
lung tumor
metabolism
nude mouse
pathology
smoking
tumor cell line
tumor invasion
Animals
Benzo(a)pyrene
beta Catenin
Biopsy
Bronchi
Carcinogenesis
Cell Line, Tumor
Cell Movement
Cell Transformation, Neoplastic
Epithelial Cells
Female
Humans
Lung
Lung Neoplasms
Mice
Mice, Inbred C57BL
Mice, Nude
Neoplasm Invasiveness
Sirtuin 1
Smoking
Transcription, Genetic
Tumor Necrosis Factor-alpha
Up-Regulation
Issue Date: 2015
Citation: Lu, J, Zhang, M, Huang, Z, Sun, S, Zhang, Y, Zhang, L, Peng, L, Ma, A, Ji, P, Dai, J, Cui, T, Liu, H, Gao, J (2015). SIRT1 in B[a]P-induced lung tumorigenesis. Oncotarget 6 (29) : 27113-27129. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4729
Rights: Attribution 4.0 International
Abstract: Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]Pinduced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressedin the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1up-regulated TNF-α and β-catenin and down-regulated the membrane fraction ofE-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesisof BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved inB[a]P-induced transformation associated with activation of the TNF-α/β-catenin axisand is as a potential therapeutic target for lung cancer.
Source Title: Oncotarget
URI: https://scholarbank.nus.edu.sg/handle/10635/180937
ISSN: 19492553
DOI: 10.18632/oncotarget.4729
Rights: Attribution 4.0 International
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