Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep11018
Title: Membrane-less microfiltration using inertial microfluidics
Authors: Warkiani, M.E
Tay, A.K.P 
Guan, G
Han, J
Keywords: animal
bioreactor
CHO cell line
Cricetulus
devices
filtration
microfluidics
Saccharomyces cerevisiae
Animals
Bioreactors
CHO Cells
Cricetulus
Filtration
Microfluidics
Saccharomyces cerevisiae
Issue Date: 2015
Publisher: Nature Publishing Group
Citation: Warkiani, M.E, Tay, A.K.P, Guan, G, Han, J (2015). Membrane-less microfiltration using inertial microfluidics. Scientific Reports 5 : 11018. ScholarBank@NUS Repository. https://doi.org/10.1038/srep11018
Rights: Attribution 4.0 International
Abstract: Microfiltration is a ubiquitous and often crucial part of many industrial processes, including biopharmaceutical manufacturing. Yet, all existing filtration systems suffer from the issue of membrane clogging, which fundamentally limits the efficiency and reliability of the filtration process. Herein, we report the development of a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (? 500a €‰mL/min). We demonstrated the systems engineered for CHO (10-20a €‰I 1/4m) and yeast (3-5a €‰I 1/4m) cells filtration, which are two main cell types used for large-scale bioreactors. Our proposed system can replace existing filtration membrane and provide passive (no external force fields), continuous filtration, thus eliminating the need for membrane replacement. This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/180455
ISSN: 2045-2322
DOI: 10.1038/srep11018
Rights: Attribution 4.0 International
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