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https://doi.org/10.1038/srep11018
Title: | Membrane-less microfiltration using inertial microfluidics | Authors: | Warkiani, M.E Tay, A.K.P Guan, G Han, J |
Keywords: | animal bioreactor CHO cell line Cricetulus devices filtration microfluidics Saccharomyces cerevisiae Animals Bioreactors CHO Cells Cricetulus Filtration Microfluidics Saccharomyces cerevisiae |
Issue Date: | 2015 | Publisher: | Nature Publishing Group | Citation: | Warkiani, M.E, Tay, A.K.P, Guan, G, Han, J (2015). Membrane-less microfiltration using inertial microfluidics. Scientific Reports 5 : 11018. ScholarBank@NUS Repository. https://doi.org/10.1038/srep11018 | Rights: | Attribution 4.0 International | Abstract: | Microfiltration is a ubiquitous and often crucial part of many industrial processes, including biopharmaceutical manufacturing. Yet, all existing filtration systems suffer from the issue of membrane clogging, which fundamentally limits the efficiency and reliability of the filtration process. Herein, we report the development of a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (? 500a €‰mL/min). We demonstrated the systems engineered for CHO (10-20a €‰I 1/4m) and yeast (3-5a €‰I 1/4m) cells filtration, which are two main cell types used for large-scale bioreactors. Our proposed system can replace existing filtration membrane and provide passive (no external force fields), continuous filtration, thus eliminating the need for membrane replacement. This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/180455 | ISSN: | 2045-2322 | DOI: | 10.1038/srep11018 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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