Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep11018
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dc.titleMembrane-less microfiltration using inertial microfluidics
dc.contributor.authorWarkiani, M.E
dc.contributor.authorTay, A.K.P
dc.contributor.authorGuan, G
dc.contributor.authorHan, J
dc.date.accessioned2020-10-26T09:03:31Z
dc.date.available2020-10-26T09:03:31Z
dc.date.issued2015
dc.identifier.citationWarkiani, M.E, Tay, A.K.P, Guan, G, Han, J (2015). Membrane-less microfiltration using inertial microfluidics. Scientific Reports 5 : 11018. ScholarBank@NUS Repository. https://doi.org/10.1038/srep11018
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/180455
dc.description.abstractMicrofiltration is a ubiquitous and often crucial part of many industrial processes, including biopharmaceutical manufacturing. Yet, all existing filtration systems suffer from the issue of membrane clogging, which fundamentally limits the efficiency and reliability of the filtration process. Herein, we report the development of a membrane-less microfiltration system by massively parallelizing inertial microfluidics to achieve a macroscopic volume processing rates (? 500a €‰mL/min). We demonstrated the systems engineered for CHO (10-20a €‰I 1/4m) and yeast (3-5a €‰I 1/4m) cells filtration, which are two main cell types used for large-scale bioreactors. Our proposed system can replace existing filtration membrane and provide passive (no external force fields), continuous filtration, thus eliminating the need for membrane replacement. This platform has the desirable combinations of high throughput, low-cost, and scalability, making it compatible for a myriad of microfiltration applications and industrial purposes.
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectanimal
dc.subjectbioreactor
dc.subjectCHO cell line
dc.subjectCricetulus
dc.subjectdevices
dc.subjectfiltration
dc.subjectmicrofluidics
dc.subjectSaccharomyces cerevisiae
dc.subjectAnimals
dc.subjectBioreactors
dc.subjectCHO Cells
dc.subjectCricetulus
dc.subjectFiltration
dc.subjectMicrofluidics
dc.subjectSaccharomyces cerevisiae
dc.typeArticle
dc.contributor.departmentDEPT OF BIOMEDICAL ENGINEERING
dc.description.doi10.1038/srep11018
dc.description.sourcetitleScientific Reports
dc.description.volume5
dc.description.page11018
dc.published.statepublished
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