Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep39872
Title: Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study
Authors: Pang, J 
Hsu, J.P
Yeo, T.W
Leo, Y.S 
Lye, D.C 
Keywords: adolescent
adult
aged
asthma
cardiovascular disease
case control study
child
complication
dengue
diabetes mellitus
female
human
male
middle aged
Adolescent
Adult
Aged
Asthma
Cardiovascular Diseases
Case-Control Studies
Child
Dengue
Diabetes Mellitus
Female
Humans
Male
Middle Aged
Issue Date: 2017
Publisher: Nature Publishing Group
Citation: Pang, J, Hsu, J.P, Yeo, T.W, Leo, Y.S, Lye, D.C (2017). Diabetes, cardiac disorders and asthma as risk factors for severe organ involvement among adult dengue patients: A matched case-control study. Scientific Reports 7 : 39872. ScholarBank@NUS Repository. https://doi.org/10.1038/srep39872
Rights: Attribution 4.0 International
Abstract: Progression to severe organ involvement due to dengue infection has been associated with severe dengue disease, intensive care treatment, and mortality. However, there is a lack of understanding of the impact of pre-existing comorbidities and other risk factors of severe organ involvement among dengue adults. The aim of this retrospective case-control study is to characterize and identify risk factors that predispose dengue adults at risk of progression with severe organ involvement. This study involved 174 dengue patients who had progressed with severe organ involvement and 865 dengue patients without severe organ involvement, matched by the year of presentation of the cases, who were admitted to Tan Tock Seng Hospital between year 2005 and 2008. Age group of 60 years or older, diabetes, cardiac disorders, asthma, and having two or more pre-existing comorbidities were independent risk factors of severe organ involvement. Abdominal pain, clinical fluid accumulation, and hematocrit rise and rapid platelet count drop at presentation were significantly associated with severe organ involvement. These risk factors, when validated in a larger study, will be useful for triage by clinicians for prompt monitoring and clinical management at first presentation, to minimize the risk of severe organ involvement and hence, disease severity. © The Author(s) 2017.
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/179745
ISSN: 2045-2322
DOI: 10.1038/srep39872
Rights: Attribution 4.0 International
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