Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10561-014-9469-2
Title: Banking of cryopreserved iliac artery and vein homografts: clinical uses in transplantation
Authors: Heng, W.L
Madhavan, K 
Wee, P
Seck, T
Lim, Y.P
Lim, C.H
Keywords: adolescent
adult
aged
allograft
allotransplantation
child
cryopreservation
cytology
human
iliac artery
iliac vein
liver transplantation
middle aged
procedures
standards
tissue bank
transplantation
young adult
Adolescent
Adult
Aged
Allografts
Child
Cryopreservation
Humans
Iliac Artery
Iliac Vein
Liver Transplantation
Middle Aged
Tissue Banks
Transplantation, Homologous
Young Adult
Issue Date: 2015
Publisher: Kluwer Academic Publishers
Citation: Heng, W.L, Madhavan, K, Wee, P, Seck, T, Lim, Y.P, Lim, C.H (2015). Banking of cryopreserved iliac artery and vein homografts: clinical uses in transplantation. Cell and Tissue Banking 16 (2) : 235-242. ScholarBank@NUS Repository. https://doi.org/10.1007/s10561-014-9469-2
Rights: Attribution 4.0 International
Abstract: Iliac artery and vein homografts are critical for revascularization in living-donor liver transplantation. Since 2010, National Cardiovascular Homograft Bank and National University Hospital have collaborated in the pioneer endeavor of banking iliac vessel homografts for such surgeries in Singapore. This article aims to demonstrate that the processing, decontamination and cryopreservation techniques that our bank follow, help preserve iliac vessel homografts for a longer duration as compared to homografts preserved using short-term preservation techniques. This paper reports the first 4 years of post-operative outcome for recipients as a preliminary report for a longer-term outcome study. Criteria for donor assessment, techniques of iliac vessel homograft recovery, processing, decontamination, cryopreservation and storage according to the American Association of Tissue Banks standards are also described. From 2010 until 2013, we discovered of the iliac vessel homografts processed, 17 (94.4 %) were suitable for clinical use. Nine iliac artery grafts (64 %) and one iliac vein graft (14 %) were implanted. Irrespective of vessel type, homografts <90 mm in length were of little use. Of the nine current iliac vessel homograft recipients, eight patients (89 %) had living-donor liver transplantation and one patient (11 %) had reconstruction of the right internal carotid artery after resection of an aneurysm. Our preliminary results supports existing literatures that suggest cryopreserved iliac vessel homografts can be successfully used for revascularization in liver transplantation and reconstruction of carotid artery. Encouraging short-term post-operative patient outcomes have been achieved, with no report of adverse event attributed to implanted homografts. We believe that our processing, decontamination and cryopreservation techniques have helped preserve the homografts for longer duration as compared to homografts preserved using short-term preservation techniques. © 2014, The Author(s).
Source Title: Cell and Tissue Banking
URI: https://scholarbank.nus.edu.sg/handle/10635/179661
ISSN: 1389-9333
DOI: 10.1007/s10561-014-9469-2
Rights: Attribution 4.0 International
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