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https://doi.org/10.1038/srep20127
Title: | Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals | Authors: | Montagner, A Korecka, A Polizzi, A Lippi, Y Blum, Y Canlet, C Tremblay-Franco, M Gautier-Stein, A Burcelin, R Yen, Y.-C Je, H.S Maha, A.-A Mithieux, G Arulampalam, V Lagarrigue, S Guillou, H Pettersson, S Wahli, W |
Keywords: | biological marker cell receptor transcriptome animal antibody specificity circadian rhythm drug inactivation female gastrointestinal tract gene expression profiling gene expression regulation genetics gluconeogenesis intestine flora liver male metabolism microbiology microflora mouse signal transduction Animals Biomarkers Circadian Clocks Female Gastrointestinal Microbiome Gastrointestinal Tract Gene Expression Profiling Gene Expression Regulation Gluconeogenesis Inactivation, Metabolic Liver Male Mice Microbiota Organ Specificity Receptors, Cytoplasmic and Nuclear Signal Transduction Transcriptome |
Issue Date: | 2016 | Citation: | Montagner, A, Korecka, A, Polizzi, A, Lippi, Y, Blum, Y, Canlet, C, Tremblay-Franco, M, Gautier-Stein, A, Burcelin, R, Yen, Y.-C, Je, H.S, Maha, A.-A, Mithieux, G, Arulampalam, V, Lagarrigue, S, Guillou, H, Pettersson, S, Wahli, W (2016). Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Scientific Reports 6 : 20127. ScholarBank@NUS Repository. https://doi.org/10.1038/srep20127 | Rights: | Attribution 4.0 International | Abstract: | The liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well known. Here, we report that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators. Mice exposed to microbes typically exhibit characterized activities of nuclear receptors, some of which (PPAR?, LXR?) regulate specific liver gene expression networks, but these activities are profoundly changed in GF mice. These alterations in microbiome-sensitive gene expression patterns are associated with daily alterations in lipid, glucose, and xenobiotic metabolism, protein turnover, and redox balance, as revealed by hepatic metabolome analyses. Moreover, at the systemic level, daily changes in the abundance of biomarkers such as HDL cholesterol, free fatty acids, FGF21, bilirubin, and lactate depend on the microbiome. Altogether, our results indicate that the microbiome is required for integration of liver clock oscillations that tune output activators and their effectors, thereby regulating metabolic gene expression for optimal liver function. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/178942 | ISSN: | 20452322 | DOI: | 10.1038/srep20127 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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