Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep20127
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dc.titleHepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
dc.contributor.authorMontagner, A
dc.contributor.authorKorecka, A
dc.contributor.authorPolizzi, A
dc.contributor.authorLippi, Y
dc.contributor.authorBlum, Y
dc.contributor.authorCanlet, C
dc.contributor.authorTremblay-Franco, M
dc.contributor.authorGautier-Stein, A
dc.contributor.authorBurcelin, R
dc.contributor.authorYen, Y.-C
dc.contributor.authorJe, H.S
dc.contributor.authorMaha, A.-A
dc.contributor.authorMithieux, G
dc.contributor.authorArulampalam, V
dc.contributor.authorLagarrigue, S
dc.contributor.authorGuillou, H
dc.contributor.authorPettersson, S
dc.contributor.authorWahli, W
dc.date.accessioned2020-10-22T03:07:25Z
dc.date.available2020-10-22T03:07:25Z
dc.date.issued2016
dc.identifier.citationMontagner, A, Korecka, A, Polizzi, A, Lippi, Y, Blum, Y, Canlet, C, Tremblay-Franco, M, Gautier-Stein, A, Burcelin, R, Yen, Y.-C, Je, H.S, Maha, A.-A, Mithieux, G, Arulampalam, V, Lagarrigue, S, Guillou, H, Pettersson, S, Wahli, W (2016). Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals. Scientific Reports 6 : 20127. ScholarBank@NUS Repository. https://doi.org/10.1038/srep20127
dc.identifier.issn20452322
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178942
dc.description.abstractThe liver is a key organ of metabolic homeostasis with functions that oscillate in response to food intake. Although liver and gut microbiome crosstalk has been reported, microbiome-mediated effects on peripheral circadian clocks and their output genes are less well known. Here, we report that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators. Mice exposed to microbes typically exhibit characterized activities of nuclear receptors, some of which (PPAR?, LXR?) regulate specific liver gene expression networks, but these activities are profoundly changed in GF mice. These alterations in microbiome-sensitive gene expression patterns are associated with daily alterations in lipid, glucose, and xenobiotic metabolism, protein turnover, and redox balance, as revealed by hepatic metabolome analyses. Moreover, at the systemic level, daily changes in the abundance of biomarkers such as HDL cholesterol, free fatty acids, FGF21, bilirubin, and lactate depend on the microbiome. Altogether, our results indicate that the microbiome is required for integration of liver clock oscillations that tune output activators and their effectors, thereby regulating metabolic gene expression for optimal liver function.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectbiological marker
dc.subjectcell receptor
dc.subjecttranscriptome
dc.subjectanimal
dc.subjectantibody specificity
dc.subjectcircadian rhythm
dc.subjectdrug inactivation
dc.subjectfemale
dc.subjectgastrointestinal tract
dc.subjectgene expression profiling
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectgluconeogenesis
dc.subjectintestine flora
dc.subjectliver
dc.subjectmale
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmicroflora
dc.subjectmouse
dc.subjectsignal transduction
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectCircadian Clocks
dc.subjectFemale
dc.subjectGastrointestinal Microbiome
dc.subjectGastrointestinal Tract
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation
dc.subjectGluconeogenesis
dc.subjectInactivation, Metabolic
dc.subjectLiver
dc.subjectMale
dc.subjectMice
dc.subjectMicrobiota
dc.subjectOrgan Specificity
dc.subjectReceptors, Cytoplasmic and Nuclear
dc.subjectSignal Transduction
dc.subjectTranscriptome
dc.typeArticle
dc.contributor.departmentDEPT OF PHYSIOLOGY
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/srep20127
dc.description.sourcetitleScientific Reports
dc.description.volume6
dc.description.page20127
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