Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41598-018-20185-8
Title: Zika virus infection elicits auto-antibodies to C1q
Authors: Koma, T
Veljkovic, V
Anderson, D.E 
Wang, L.-F 
Rossi, S.L
Shan, C
Shi, P.-Y 
Beasley, D.W
Bukreyeva, N
Smith, J.N
Hallam, S
Huang, C
Von Messling, V 
Paessler, S
Keywords: autoantibody
complement component C1q
neutralizing antibody
virus antibody
animal
Guillain Barre syndrome
immunology
Macaca fascicularis
microcephaly
mouse
virology
Zika fever
Zika virus
Animals
Antibodies, Neutralizing
Antibodies, Viral
Autoantibodies
Complement C1q
Guillain-Barre Syndrome
Macaca fascicularis
Mice
Microcephaly
Zika Virus
Zika Virus Infection
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Koma, T, Veljkovic, V, Anderson, D.E, Wang, L.-F, Rossi, S.L, Shan, C, Shi, P.-Y, Beasley, D.W, Bukreyeva, N, Smith, J.N, Hallam, S, Huang, C, Von Messling, V, Paessler, S (2018). Zika virus infection elicits auto-antibodies to C1q. Scientific Reports 8 (1) : 1882. ScholarBank@NUS Repository. https://doi.org/10.1038/s41598-018-20185-8
Rights: Attribution 4.0 International
Abstract: Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barré syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future. © 2018 The Author(s).
Source Title: Scientific Reports
URI: https://scholarbank.nus.edu.sg/handle/10635/178457
ISSN: 2045-2322
DOI: 10.1038/s41598-018-20185-8
Rights: Attribution 4.0 International
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