Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-02975-w
Title: Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
Authors: Li, X.-F
Dong, H.-L
Wang, H.-J
Huang, X.-Y
Qiu, Y.-F
Ji, X
Ye, Q
Li, C
Liu, Y
Deng, Y.-Q
Jiang, T
Cheng, G
Zhang, F.-C
Davidson, A.D
Song, Y.-J
Shi, P.-Y 
Qin, C.-F
Keywords: epidermal growth factor receptor
gamma interferon
gamma interferon inducible protein 10
granulocyte macrophage colony stimulating factor
immunoglobulin G
interleukin 10
interleukin 15
interleukin 1beta
interleukin 2
interleukin 8
Japanese encephalitis vaccine
live vaccine
macrophage inflammatory protein 1beta
macrophage migration inhibition factor
monocyte chemotactic protein 1
neutralizing antibody
RANTES
sa 14 14 2
virus RNA
Zika virus vaccine
live vaccine
neutralizing antibody
recombinant vaccine
virus antibody
virus vaccine
encephalitis
gene expression
genetic analysis
immune response
immunization
phenotype
protein
vaccine
Zika virus disease
animal experiment
animal model
animal tissue
antibody blood level
Article
cellular immunity
controlled study
cytokine production
drug efficacy
female
genetic stability
in vitro study
in vivo study
infection prevention
male
mouse
nonhuman
protein blood level
rhesus monkey
single drug dose
vaccination
vaccine immunogenicity
virus attenuation
Zika fever
129 mouse
Aedes
animal
Bagg albino mouse
biosynthesis
disease model
genetic engineering
genetics
human
immunology
Japanese encephalitis virus
mosquito vector
pregnancy
prevention and control
vertical transmission
viremia
virology
Zika fever
Zika virus
Animalia
Flavivirus
Japanese encephalitis virus
Macaca mulatta
Mus
Zika virus
Aedes
Animals
Antibodies, Neutralizing
Antibodies, Viral
Disease Models, Animal
Encephalitis Virus, Japanese
Female
Genetic Engineering
Humans
Infectious Disease Transmission, Vertical
Macaca mulatta
Male
Mice
Mice, 129 Strain
Mice, Inbred BALB C
Mosquito Vectors
Pregnancy
Vaccines, Attenuated
Vaccines, Synthetic
Viral Vaccines
Viremia
Zika Virus
Zika Virus Infection
Issue Date: 2018
Publisher: Nature Publishing Group
Citation: Li, X.-F, Dong, H.-L, Wang, H.-J, Huang, X.-Y, Qiu, Y.-F, Ji, X, Ye, Q, Li, C, Liu, Y, Deng, Y.-Q, Jiang, T, Cheng, G, Zhang, F.-C, Davidson, A.D, Song, Y.-J, Shi, P.-Y, Qin, C.-F (2018). Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone. Nature Communications 9 (1) : 673. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-02975-w
Rights: Attribution 4.0 International
Abstract: The global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models. Remarkably, immunization of mice and rhesus macaques with a single dose of ChinZIKV elicits robust and long-lasting immune responses, and confers complete protection against ZIKV challenge. Significantly, female mice immunized with ChinZIKV are protected against placental and fetal damage upon ZIKV challenge during pregnancy. Overall, our study provides an alternative vaccine platform in response to the ZIKV emergency, and the safety, immunogenicity, and protection profiles of ChinZIKV warrant further clinical development. © 2018 The Author(s).
Source Title: Nature Communications
URI: https://scholarbank.nus.edu.sg/handle/10635/178453
ISSN: 2041-1723
DOI: 10.1038/s41467-018-02975-w
Rights: Attribution 4.0 International
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