Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41467-018-02975-w
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dc.titleDevelopment of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone
dc.contributor.authorLi, X.-F
dc.contributor.authorDong, H.-L
dc.contributor.authorWang, H.-J
dc.contributor.authorHuang, X.-Y
dc.contributor.authorQiu, Y.-F
dc.contributor.authorJi, X
dc.contributor.authorYe, Q
dc.contributor.authorLi, C
dc.contributor.authorLiu, Y
dc.contributor.authorDeng, Y.-Q
dc.contributor.authorJiang, T
dc.contributor.authorCheng, G
dc.contributor.authorZhang, F.-C
dc.contributor.authorDavidson, A.D
dc.contributor.authorSong, Y.-J
dc.contributor.authorShi, P.-Y
dc.contributor.authorQin, C.-F
dc.date.accessioned2020-10-20T09:58:38Z
dc.date.available2020-10-20T09:58:38Z
dc.date.issued2018
dc.identifier.citationLi, X.-F, Dong, H.-L, Wang, H.-J, Huang, X.-Y, Qiu, Y.-F, Ji, X, Ye, Q, Li, C, Liu, Y, Deng, Y.-Q, Jiang, T, Cheng, G, Zhang, F.-C, Davidson, A.D, Song, Y.-J, Shi, P.-Y, Qin, C.-F (2018). Development of a chimeric Zika vaccine using a licensed live-attenuated flavivirus vaccine as backbone. Nature Communications 9 (1) : 673. ScholarBank@NUS Repository. https://doi.org/10.1038/s41467-018-02975-w
dc.identifier.issn2041-1723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/178453
dc.description.abstractThe global spread of Zika virus (ZIKV) and its unexpected association with congenital defects necessitates the rapid development of a safe and effective vaccine. Here we report the development and characterization of a recombinant chimeric ZIKV vaccine candidate (termed ChinZIKV) that expresses the prM-E proteins of ZIKV using the licensed Japanese encephalitis live-attenuated vaccine SA14-14-2 as the genetic backbone. ChinZIKV retains its replication activity and genetic stability in vitro, while exhibiting an attenuation phenotype in multiple animal models. Remarkably, immunization of mice and rhesus macaques with a single dose of ChinZIKV elicits robust and long-lasting immune responses, and confers complete protection against ZIKV challenge. Significantly, female mice immunized with ChinZIKV are protected against placental and fetal damage upon ZIKV challenge during pregnancy. Overall, our study provides an alternative vaccine platform in response to the ZIKV emergency, and the safety, immunogenicity, and protection profiles of ChinZIKV warrant further clinical development. © 2018 The Author(s).
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectepidermal growth factor receptor
dc.subjectgamma interferon
dc.subjectgamma interferon inducible protein 10
dc.subjectgranulocyte macrophage colony stimulating factor
dc.subjectimmunoglobulin G
dc.subjectinterleukin 10
dc.subjectinterleukin 15
dc.subjectinterleukin 1beta
dc.subjectinterleukin 2
dc.subjectinterleukin 8
dc.subjectJapanese encephalitis vaccine
dc.subjectlive vaccine
dc.subjectmacrophage inflammatory protein 1beta
dc.subjectmacrophage migration inhibition factor
dc.subjectmonocyte chemotactic protein 1
dc.subjectneutralizing antibody
dc.subjectRANTES
dc.subjectsa 14 14 2
dc.subjectvirus RNA
dc.subjectZika virus vaccine
dc.subjectlive vaccine
dc.subjectneutralizing antibody
dc.subjectrecombinant vaccine
dc.subjectvirus antibody
dc.subjectvirus vaccine
dc.subjectencephalitis
dc.subjectgene expression
dc.subjectgenetic analysis
dc.subjectimmune response
dc.subjectimmunization
dc.subjectphenotype
dc.subjectprotein
dc.subjectvaccine
dc.subjectZika virus disease
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantibody blood level
dc.subjectArticle
dc.subjectcellular immunity
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectdrug efficacy
dc.subjectfemale
dc.subjectgenetic stability
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectinfection prevention
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein blood level
dc.subjectrhesus monkey
dc.subjectsingle drug dose
dc.subjectvaccination
dc.subjectvaccine immunogenicity
dc.subjectvirus attenuation
dc.subjectZika fever
dc.subject129 mouse
dc.subjectAedes
dc.subjectanimal
dc.subjectBagg albino mouse
dc.subjectbiosynthesis
dc.subjectdisease model
dc.subjectgenetic engineering
dc.subjectgenetics
dc.subjecthuman
dc.subjectimmunology
dc.subjectJapanese encephalitis virus
dc.subjectmosquito vector
dc.subjectpregnancy
dc.subjectprevention and control
dc.subjectvertical transmission
dc.subjectviremia
dc.subjectvirology
dc.subjectZika fever
dc.subjectZika virus
dc.subjectAnimalia
dc.subjectFlavivirus
dc.subjectJapanese encephalitis virus
dc.subjectMacaca mulatta
dc.subjectMus
dc.subjectZika virus
dc.subjectAedes
dc.subjectAnimals
dc.subjectAntibodies, Neutralizing
dc.subjectAntibodies, Viral
dc.subjectDisease Models, Animal
dc.subjectEncephalitis Virus, Japanese
dc.subjectFemale
dc.subjectGenetic Engineering
dc.subjectHumans
dc.subjectInfectious Disease Transmission, Vertical
dc.subjectMacaca mulatta
dc.subjectMale
dc.subjectMice
dc.subjectMice, 129 Strain
dc.subjectMice, Inbred BALB C
dc.subjectMosquito Vectors
dc.subjectPregnancy
dc.subjectVaccines, Attenuated
dc.subjectVaccines, Synthetic
dc.subjectViral Vaccines
dc.subjectViremia
dc.subjectZika Virus
dc.subjectZika Virus Infection
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.description.doi10.1038/s41467-018-02975-w
dc.description.sourcetitleNature Communications
dc.description.volume9
dc.description.issue1
dc.description.page673
dc.published.statepublished
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