Please use this identifier to cite or link to this item: https://doi.org/10.1186/1748-717X-4-23
Title: Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: Analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01)
Authors: Loong, S.L.E
Hwang, J.S.G 
Li, H.H 
Wee, J.T.S 
Yap, S.P
Chua, M.L.K 
Fong, K.W
Tan, T.W.K 
Keywords: cisplatin
cyclooxygenase 2
fluorouracil
antineoplastic agent
cyclooxygenase 2
PTGS2 protein, human
adjuvant therapy
adult
aged
article
cancer chemotherapy
cancer radiotherapy
cancer staging
cancer survival
cohort analysis
controlled study
female
human
human tissue
immunohistochemistry
major clinical study
male
multiple cycle treatment
nasopharynx carcinoma
overall survival
prognosis
protein expression
treatment response
adolescent
clinical trial
comparative study
enzymology
metabolism
middle aged
multimodality cancer therapy
nasopharynx tumor
phase 3 clinical trial
radiation dose
randomized controlled trial
survival rate
treatment outcome
Adolescent
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
Clinical Trials, Phase III as Topic
Combined Modality Therapy
Cyclooxygenase 2
Female
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms
Neoplasm Staging
Prognosis
Radiotherapy Dosage
Randomized Controlled Trials as Topic
Survival Rate
Treatment Outcome
Young Adult
Issue Date: 2009
Publisher: BMC
Citation: Loong, S.L.E, Hwang, J.S.G, Li, H.H, Wee, J.T.S, Yap, S.P, Chua, M.L.K, Fong, K.W, Tan, T.W.K (2009). Weak expression of cyclooxygenase-2 is associated with poorer outcome in endemic nasopharyngeal carcinoma: Analysis of data from randomized trial between radiation alone versus concurrent chemo-radiation (SQNP-01). Radiation Oncology 4 : 23. ScholarBank@NUS Repository. https://doi.org/10.1186/1748-717X-4-23
Rights: Attribution 4.0 International
Abstract: Background: Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our randomized trial of radiation versus concurrent chemoradiation in endemic NPC, we analyzed a cohort of tumour samples collected from participants from one referral hospital. Methods: 58 out of 88 patients from this institution had samples available for analysis. COX-2 expression levels were stratified by immunohistochemistry, into negligible, weak, moderate and strong, and correlated with overall and disease specific survivals. Results: 58% had negligible or weak COX-2 expression, while 14% and 28% had moderate and strong expression respectively. Weak COX-2 expression conferred a poorer median overall survival, 1.3 years for weak versus 6.3 years for negligible, 7.8 years, strong and not reached for moderate. There was a similar trend for disease specific survival. Conclusion: Contrary to literature published on other malignancies, our findings seemed to indicate that over-expression of COX-2 confer a better prognosis in patients with endemic NPC. Larger studies are required to conclusively determine the significance of COX-2 expression in these patients. © 2009 Loong et al; licensee BioMed Central Ltd.
Source Title: Radiation Oncology
URI: https://scholarbank.nus.edu.sg/handle/10635/178221
ISSN: 1748-717X
DOI: 10.1186/1748-717X-4-23
Rights: Attribution 4.0 International
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