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Title: 'Prechronous' metastasis in clear cell renal cell carcinoma: A case report
Authors: Poon, E
Ong, S.J 
Chuang, X.E
Lim, W.T 
Mohd Zam, N.A 
Chong, T.W 
Al Jajeh, I
Mancer, K
Tan, M.-H 
Keywords: CD103 antigen
melan A
adrenal cortex tumor
bone scintiscanning
cancer chemotherapy
case report
clear cell carcinoma
computer assisted tomography
human tissue
kidney carcinoma
lung lesion
lung metastasis
lung nodule
multiple cycle treatment
prechronous metastasis
priority journal
thorax radiography
transthoracic aspiration
weight reduction
Issue Date: 2011
Publisher: BMC
Citation: Poon, E, Ong, S.J, Chuang, X.E, Lim, W.T, Mohd Zam, N.A, Chong, T.W, Al Jajeh, I, Mancer, K, Tan, M.-H (2011). 'Prechronous' metastasis in clear cell renal cell carcinoma: A case report. Journal of Medical Case Reports 5 : 181. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Introduction. Although metastatic carcinoma in the presence of an occult primary tumor is well recognized, underlying reasons for the failure of the primary tumor to manifest are uncertain. Explanations for this phenomenon have ranged from spontaneous regression of the primary tumor to early metastasis of the primary tumor before manifestation of a less aggressive primary tumor. We report a case of 'prechronous' metastasis arising from clear cell renal cell carcinoma, where metastatic disease initially manifested in the absence of a primary renal tumor, followed by aggressive growth of the primary renal lesion. Case presentation. A 43-year-old Malay man initially presented to our facility with fever and cough. He subsequently underwent surgical resection of a 9 cm right-sided lung mass found on radiological examination. Histology showed a high-grade clear cell tumor with sarcomatoid differentiation, suggestive of a metastasis from clear cell renal cell carcinoma. However, no concurrent renal lesions were noted on computed tomographic evaluation at that time. Then, four months after lung resection, he presented with a subcutaneous mass in the left loin, as well as right loin discomfort. Computed tomography scanning revealed a 10 cm right renal mass, with renal vein and inferior vena cava invasion, as well as recurrent disease in the right thorax. Histological examination of the excised subcutaneous mass revealed a high-grade carcinoma consistent with clear cell renal cell carcinoma. Conclusions: This is the first reported case of prechronous metastasis of renal cell carcinoma, with metastatic disease manifesting prior to the development of the primary lesion. The underlying mechanism is uncertain, but our patient's case provides anecdotal support for the early dissemination model of metastasis. © 2011 Poon et al; licensee BioMed Central Ltd.
Source Title: Journal of Medical Case Reports
ISSN: 1752-1947
DOI: 10.1186/1752-1947-5-181
Rights: Attribution 4.0 International
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