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https://doi.org/10.1038/ncomms5988
| Title: | Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer | Authors: | Pritchard, C.C Morrissey, C Kumar, A Zhang, X Smith, C Coleman, I Salipante, S.J Milbank, J Yu, M Grady, W.M Tait, J.F Corey, E Vessella, R.L Walsh, T Shendure, J Nelson, P.S |
Keywords: | protein MSH2 protein MSH6 DNA binding protein G-T mismatch-binding protein MSH2 protein, human protein binding protein MSH2 cancer disease incidence gene expression genetic differentiation microstructure mutation advanced cancer Article autopsy bioinformatics cancer growth controlled study copy number variation disease assessment disease association DNA repair frameshift mutation gene mutation gene rearrangement human human tissue loss of function mutation male microsatellite instability mismatch repair prostate cancer protein expression enzymology genetics metabolism middle aged mutation prostate tumor DNA Mismatch Repair DNA-Binding Proteins Humans Male Microsatellite Instability Middle Aged Mutation MutS Homolog 2 Protein Prostatic Neoplasms Protein Binding |
Issue Date: | 2014 | Publisher: | Nature Publishing Group | Citation: | Pritchard, C.C, Morrissey, C, Kumar, A, Zhang, X, Smith, C, Coleman, I, Salipante, S.J, Milbank, J, Yu, M, Grady, W.M, Tait, J.F, Corey, E, Vessella, R.L, Walsh, T, Shendure, J, Nelson, P.S (2014). Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer. Nature Communications 5 : 4988. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms5988 | Rights: | Attribution 4.0 International | Abstract: | A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (MSI). Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers. © 2014 Macmillan Publishers Limited. All rights reserved. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/177773 | ISSN: | 20411723 | DOI: | 10.1038/ncomms5988 | Rights: | Attribution 4.0 International |
| Appears in Collections: | Staff Publications Elements |
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