1. ScholarBank@NUS
  2. 1. Staff
  3. Staff Publications
Please use this identifier to cite or link to this item: https://doi.org/10.1038/ncomms5988
DC FieldValue
dc.titleComplex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
dc.contributor.authorPritchard, C.C
dc.contributor.authorMorrissey, C
dc.contributor.authorKumar, A
dc.contributor.authorZhang, X
dc.contributor.authorSmith, C
dc.contributor.authorColeman, I
dc.contributor.authorSalipante, S.J
dc.contributor.authorMilbank, J
dc.contributor.authorYu, M
dc.contributor.authorGrady, W.M
dc.contributor.authorTait, J.F
dc.contributor.authorCorey, E
dc.contributor.authorVessella, R.L
dc.contributor.authorWalsh, T
dc.contributor.authorShendure, J
dc.contributor.authorNelson, P.S
dc.date.accessioned2020-10-20T03:18:29Z
dc.date.available2020-10-20T03:18:29Z
dc.date.issued2014
dc.identifier.citationPritchard, C.C, Morrissey, C, Kumar, A, Zhang, X, Smith, C, Coleman, I, Salipante, S.J, Milbank, J, Yu, M, Grady, W.M, Tait, J.F, Corey, E, Vessella, R.L, Walsh, T, Shendure, J, Nelson, P.S (2014). Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer. Nature Communications 5 : 4988. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms5988
dc.identifier.issn20411723
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/177773
dc.description.abstractA hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancers have mismatch repair gene mutations and microsatellite instability (MSI). Mutations are frequently complex MSH2 or MSH6 structural rearrangements rather than MLH1 epigenetic silencing. Our findings identify parallels and differences in the mechanisms of hypermutation in prostate cancer compared with other MSI-associated cancers. © 2014 Macmillan Publishers Limited. All rights reserved.
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceUnpaywall 20201031
dc.subjectprotein MSH2
dc.subjectprotein MSH6
dc.subjectDNA binding protein
dc.subjectG-T mismatch-binding protein
dc.subjectMSH2 protein, human
dc.subjectprotein binding
dc.subjectprotein MSH2
dc.subjectcancer
dc.subjectdisease incidence
dc.subjectgene expression
dc.subjectgenetic differentiation
dc.subjectmicrostructure
dc.subjectmutation
dc.subjectadvanced cancer
dc.subjectArticle
dc.subjectautopsy
dc.subjectbioinformatics
dc.subjectcancer growth
dc.subjectcontrolled study
dc.subjectcopy number variation
dc.subjectdisease assessment
dc.subjectdisease association
dc.subjectDNA repair
dc.subjectframeshift mutation
dc.subjectgene mutation
dc.subjectgene rearrangement
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectloss of function mutation
dc.subjectmale
dc.subjectmicrosatellite instability
dc.subjectmismatch repair
dc.subjectprostate cancer
dc.subjectprotein expression
dc.subjectenzymology
dc.subjectgenetics
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectmutation
dc.subjectprostate tumor
dc.subjectDNA Mismatch Repair
dc.subjectDNA-Binding Proteins
dc.subjectHumans
dc.subjectMale
dc.subjectMicrosatellite Instability
dc.subjectMiddle Aged
dc.subjectMutation
dc.subjectMutS Homolog 2 Protein
dc.subjectProstatic Neoplasms
dc.subjectProtein Binding
dc.typeArticle
dc.contributor.departmentELECTRICAL AND COMPUTER ENGINEERING
dc.description.doi10.1038/ncomms5988
dc.description.sourcetitleNature Communications
dc.description.volume5
dc.description.page4988
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1038_ncomms5988.pdf608.3 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons