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https://doi.org/10.1038/s41398-018-0213-8
Title: | Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder | Authors: | Qian, X Loo, B.R.Y Castellanos, F.X Liu, S Koh, H.L Poh, X.W.W Krishnan, R Fung, D Chee, M.W Guan, C Lee, T.-S Lim, C.G Zhou, J |
Keywords: | Article attention deficit disorder brain computer interface brain maturation child Child Behavior Checklist controlled study default mode network electroencephalogram executive function functional connectivity functional magnetic resonance imaging human image analysis major clinical study male neuroimaging neuropsychological test task positive network ventral attention network attention deficit disorder brain brain mapping cluster analysis defense mechanism diagnostic imaging nerve tract nuclear magnetic resonance imaging pathophysiology psychology randomized controlled trial restlessness Singapore Attention Deficit Disorder with Hyperactivity Brain Brain Mapping Brain-Computer Interfaces Child Cluster Analysis Defense Mechanisms Executive Function Humans Magnetic Resonance Imaging Male Neural Pathways Psychomotor Agitation Singapore |
Issue Date: | 2018 | Citation: | Qian, X, Loo, B.R.Y, Castellanos, F.X, Liu, S, Koh, H.L, Poh, X.W.W, Krishnan, R, Fung, D, Chee, M.W, Guan, C, Lee, T.-S, Lim, C.G, Zhou, J (2018). Brain-computer-interface-based intervention re-normalizes brain functional network topology in children with attention deficit/hyperactivity disorder. Translational Psychiatry 8 (1) : 149. ScholarBank@NUS Repository. https://doi.org/10.1038/s41398-018-0213-8 | Abstract: | A brain-computer-interface (BCI)-based attention training game system has shown promise for treating attention deficit/hyperactivity disorder (ADHD) children with inattentive symptoms. However, little is known about brain network organizational changes underlying behavior improvement following BCI-based training. To cover this gap, we aimed to examine the topological alterations of large-scale brain functional networks induced by the 8-week BCI-based attention intervention in ADHD boys using resting-state functional magnetic resonance imaging method. Compared to the non-intervention (ADHD-NI) group, the intervention group (ADHD-I) showed greater reduction of inattention symptoms accompanied with differential brain network reorganizations after training. Specifically, the ADHD-NI group had increased functional connectivity (FC) within the salience/ventral attention network (SVN) and increased FC between task-positive networks (including the SVN, dorsal attention (DAN), somatomotor, and executive control network) and subcortical regions; in contrast ADHD-I group did not have this pattern. In parallel, ADHD-I group had reduced degree centrality and clustering coefficient as well as increased closeness in task-positive and the default mode networks (prefrontal regions) after the training. More importantly, these reduced local functional processing mainly in the SVN were associated with less inattentive/internalizing problems after 8-week BCI-based intervention across ADHD patients. Our findings suggest that the BCI-based attention training facilitates behavioral improvement in ADHD children by reorganizing brain functional network from more regular to more random configurations, particularly renormalizing salience network processing. Future long-term longitudinal neuroimaging studies are needed to develop the BCI-based intervention approach to promote brain maturation in ADHD. © 2018, The Author(s). | Source Title: | Translational Psychiatry | URI: | https://scholarbank.nus.edu.sg/handle/10635/176030 | ISSN: | 2158-3188 | DOI: | 10.1038/s41398-018-0213-8 |
Appears in Collections: | Elements Staff Publications |
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