Please use this identifier to cite or link to this item: https://doi.org/10.3390/metabo9010014
Title: Serum amino acids in association with prevalent and incident type 2 diabetes in a Chinese population
Authors: Lu, Y 
Wang, Y 
Liang, X 
Zou, L 
Ong, C.N 
Yuan, J.-M
Koh, W.-P 
Pan, A
Keywords: alanine
amino acid
glucose
glutamic acid
glutamine
glycine
hemoglobin A1c
high density lipoprotein cholesterol
insulin
isoleucine
leucine
lysine
phenylalanine
triacylglycerol
tryptophan
tyrosine
valine
adult
aged
amino acid analysis
Article
body mass
case control study
Chinese
female
glucose blood level
high performance liquid chromatography
human
hypertension
incidence
insulin resistance
limit of detection
liquid chromatography-mass spectrometry
major clinical study
male
mass spectrometry
metabolomics
non insulin dependent diabetes mellitus
predictive value
prevalence
quality control
questionnaire
receiver operating characteristic
risk assessment
risk factor
sensitivity and specificity
smoking
ultra performance liquid chromatography
Issue Date: 2019
Citation: Lu, Y, Wang, Y, Liang, X, Zou, L, Ong, C.N, Yuan, J.-M, Koh, W.-P, Pan, A (2019). Serum amino acids in association with prevalent and incident type 2 diabetes in a Chinese population. Metabolites 9 (1) : 14;. ScholarBank@NUS Repository. https://doi.org/10.3390/metabo9010014
Abstract: We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Metabolites
URI: https://scholarbank.nus.edu.sg/handle/10635/176026
ISSN: 2218-1989
DOI: 10.3390/metabo9010014
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