Please use this identifier to cite or link to this item: https://doi.org/10.3390/metabo9010014
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dc.titleSerum amino acids in association with prevalent and incident type 2 diabetes in a Chinese population
dc.contributor.authorLu, Y
dc.contributor.authorWang, Y
dc.contributor.authorLiang, X
dc.contributor.authorZou, L
dc.contributor.authorOng, C.N
dc.contributor.authorYuan, J.-M
dc.contributor.authorKoh, W.-P
dc.contributor.authorPan, A
dc.date.accessioned2020-09-14T07:46:40Z
dc.date.available2020-09-14T07:46:40Z
dc.date.issued2019
dc.identifier.citationLu, Y, Wang, Y, Liang, X, Zou, L, Ong, C.N, Yuan, J.-M, Koh, W.-P, Pan, A (2019). Serum amino acids in association with prevalent and incident type 2 diabetes in a Chinese population. Metabolites 9 (1) : 14;. ScholarBank@NUS Repository. https://doi.org/10.3390/metabo9010014
dc.identifier.issn2218-1989
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/176026
dc.description.abstractWe aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population. A case-control study was nested within the Singapore Chinese Health Study. Participants included 144 cases with prevalent and 160 cases with incident type 2 diabetes and 304 controls. Cases and controls were individually matched on age, sex, and date of blood collection. Baseline serum levels of 9 essential and 10 non-essential amino acids were measured using liquid chromatography tandem mass spectrometry. We identified that five essential (isoleucine, leucine, lysine, phenylalanine, and valine) and five non-essential (alanine, glutamic acid, glutamine, glycine, and tyrosine) amino acids were associated with the prevalence of type 2 diabetes; four essential (isoleucine, leucine, tryptophan, and valine) and two non-essential (glutamine and tyrosine) amino acids were associated with the incidence of type 2 diabetes. Of these, valine and tyrosine independently led to a significant improvement in risk prediction of incident type 2 diabetes. This study demonstrates that both essential and non-essential amino acids were associated with the risk for prevalent and incident type 2 diabetes, and the findings could aid in diabetes risk assessment in this Chinese population. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.sourceUnpaywall 20200831
dc.subjectalanine
dc.subjectamino acid
dc.subjectglucose
dc.subjectglutamic acid
dc.subjectglutamine
dc.subjectglycine
dc.subjecthemoglobin A1c
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjectisoleucine
dc.subjectleucine
dc.subjectlysine
dc.subjectphenylalanine
dc.subjecttriacylglycerol
dc.subjecttryptophan
dc.subjecttyrosine
dc.subjectvaline
dc.subjectadult
dc.subjectaged
dc.subjectamino acid analysis
dc.subjectArticle
dc.subjectbody mass
dc.subjectcase control study
dc.subjectChinese
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthypertension
dc.subjectincidence
dc.subjectinsulin resistance
dc.subjectlimit of detection
dc.subjectliquid chromatography-mass spectrometry
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmass spectrometry
dc.subjectmetabolomics
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectpredictive value
dc.subjectprevalence
dc.subjectquality control
dc.subjectquestionnaire
dc.subjectreceiver operating characteristic
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsensitivity and specificity
dc.subjectsmoking
dc.subjectultra performance liquid chromatography
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentNUS ENVIRONMENTAL RESEARCH INSTITUTE
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.description.doi10.3390/metabo9010014
dc.description.sourcetitleMetabolites
dc.description.volume9
dc.description.issue1
dc.description.page14;
dc.published.statePublished
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