Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers6010079
Title: The complex relationship between liver cancer and the cell cycle: A story of multiple regulations
Authors: Bisteau, X
Caldez, M.J
Kaldis, P 
Keywords: cyclin D1
cyclin dependent kinase
cyclin dependent kinase 1
cyclin dependent kinase 2
cyclin dependent kinase 4
cyclin dependent kinase 6
cyclin E
cycline
palbociclib
protein p16
protein p21
protein p27
protein p53
Ras protein
retinoblastoma protein
roscovitine
S phase kinase associated protein 2
sorafenib
advanced cancer
apoptosis
cell cycle progression
cell cycle regulation
cell death
cell proliferation
genomic instability
human
liver cancer
liver carcinogenesis
liver cell
liver cell carcinoma
liver fibrosis
liver regeneration
liver structure
nonhuman
oncogene
polyploidy
review
tumor suppressor gene
Issue Date: 2014
Citation: Bisteau, X, Caldez, M.J, Kaldis, P (2014). The complex relationship between liver cancer and the cell cycle: A story of multiple regulations. Cancers 6 (1) : 79-111. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers6010079
Abstract: The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation. © 2014 by the authors; licensee MDPI, Basel, Switzerland.
Source Title: Cancers
URI: https://scholarbank.nus.edu.sg/handle/10635/176015
ISSN: 2072-6694
DOI: 10.3390/cancers6010079
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