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https://doi.org/10.3390/cancers6010079
| Title: | The complex relationship between liver cancer and the cell cycle: A story of multiple regulations | Authors: | Bisteau, X Caldez, M.J Kaldis, P |
Keywords: | cyclin D1 cyclin dependent kinase cyclin dependent kinase 1 cyclin dependent kinase 2 cyclin dependent kinase 4 cyclin dependent kinase 6 cyclin E cycline palbociclib protein p16 protein p21 protein p27 protein p53 Ras protein retinoblastoma protein roscovitine S phase kinase associated protein 2 sorafenib advanced cancer apoptosis cell cycle progression cell cycle regulation cell death cell proliferation genomic instability human liver cancer liver carcinogenesis liver cell liver cell carcinoma liver fibrosis liver regeneration liver structure nonhuman oncogene polyploidy review tumor suppressor gene |
Issue Date: | 2014 | Citation: | Bisteau, X, Caldez, M.J, Kaldis, P (2014). The complex relationship between liver cancer and the cell cycle: A story of multiple regulations. Cancers 6 (1) : 79-111. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers6010079 | Abstract: | The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation. © 2014 by the authors; licensee MDPI, Basel, Switzerland. | Source Title: | Cancers | URI: | https://scholarbank.nus.edu.sg/handle/10635/176015 | ISSN: | 2072-6694 | DOI: | 10.3390/cancers6010079 |
| Appears in Collections: | Elements Staff Publications |
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| 10_3390_cancers6010079.pdf | 1.66 MB | Adobe PDF | OPEN | None | View/Download |
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