Please use this identifier to cite or link to this item: https://doi.org/10.3390/cancers6010079
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dc.titleThe complex relationship between liver cancer and the cell cycle: A story of multiple regulations
dc.contributor.authorBisteau, X
dc.contributor.authorCaldez, M.J
dc.contributor.authorKaldis, P
dc.date.accessioned2020-09-14T07:43:56Z
dc.date.available2020-09-14T07:43:56Z
dc.date.issued2014
dc.identifier.citationBisteau, X, Caldez, M.J, Kaldis, P (2014). The complex relationship between liver cancer and the cell cycle: A story of multiple regulations. Cancers 6 (1) : 79-111. ScholarBank@NUS Repository. https://doi.org/10.3390/cancers6010079
dc.identifier.issn2072-6694
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/176015
dc.description.abstractThe liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation. © 2014 by the authors; licensee MDPI, Basel, Switzerland.
dc.sourceUnpaywall 20200831
dc.subjectcyclin D1
dc.subjectcyclin dependent kinase
dc.subjectcyclin dependent kinase 1
dc.subjectcyclin dependent kinase 2
dc.subjectcyclin dependent kinase 4
dc.subjectcyclin dependent kinase 6
dc.subjectcyclin E
dc.subjectcycline
dc.subjectpalbociclib
dc.subjectprotein p16
dc.subjectprotein p21
dc.subjectprotein p27
dc.subjectprotein p53
dc.subjectRas protein
dc.subjectretinoblastoma protein
dc.subjectroscovitine
dc.subjectS phase kinase associated protein 2
dc.subjectsorafenib
dc.subjectadvanced cancer
dc.subjectapoptosis
dc.subjectcell cycle progression
dc.subjectcell cycle regulation
dc.subjectcell death
dc.subjectcell proliferation
dc.subjectgenomic instability
dc.subjecthuman
dc.subjectliver cancer
dc.subjectliver carcinogenesis
dc.subjectliver cell
dc.subjectliver cell carcinoma
dc.subjectliver fibrosis
dc.subjectliver regeneration
dc.subjectliver structure
dc.subjectnonhuman
dc.subjectoncogene
dc.subjectpolyploidy
dc.subjectreview
dc.subjecttumor suppressor gene
dc.typeReview
dc.contributor.departmentDEPT OF BIOCHEMISTRY
dc.description.doi10.3390/cancers6010079
dc.description.sourcetitleCancers
dc.description.volume6
dc.description.issue1
dc.description.page79-111
dc.published.statePublished
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