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https://doi.org/10.1161/JAHA.115.002956
Title: | Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians | Authors: | Santhanakrishnan, R Wang, N Larson, M.G Magnani, J.M Vasan, R.S Wang, T.J Yap, J Feng, L Yap, K.B Ong, H.Y Ng, T.P Richards, A.M Lam, C.S.P Ho, J.E |
Keywords: | aged Article Asian cardiovascular risk Caucasian controlled study electrocardiography female follow up human male mortality rate PR interval priority journal prognosis QT interval race difference action potential Asian continental ancestry group Cardiovascular Diseases Caucasian clinical trial comparative study epidemiology ethnology health disparity heart muscle conduction system heart rate Hypertrophy, Left Ventricular Kaplan Meier method longitudinal study Massachusetts middle aged mortality multicenter study multivariate analysis pathophysiology predictive value prognosis proportional hazards model prospective study risk assessment risk factor sex difference Singapore statistical model time factor very elderly Action Potentials Aged Aged, 80 and over Asian Continental Ancestry Group Cardiovascular Diseases Electrocardiography European Continental Ancestry Group Female Health Status Disparities Heart Conduction System Heart Rate Humans Hypertrophy, Left Ventricular Kaplan-Meier Estimate Linear Models Longitudinal Studies Male Massachusetts Middle Aged Multivariate Analysis Predictive Value of Tests Prognosis Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors Sex Factors Singapore Time Factors |
Issue Date: | 2015 | Citation: | Santhanakrishnan, R, Wang, N, Larson, M.G, Magnani, J.M, Vasan, R.S, Wang, T.J, Yap, J, Feng, L, Yap, K.B, Ong, H.Y, Ng, T.P, Richards, A.M, Lam, C.S.P, Ho, J.E (2015). Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians. Journal of the American Heart Association 5 (3) : e002956. ScholarBank@NUS Repository. https://doi.org/10.1161/JAHA.115.002956 | Abstract: | Background: Racial differences in electrocardiographic (ECG) characteristics and prognostic significance among Whites and Asians are not well described. Methods and Results: We studied 2677 White Framingham Heart Study participants (57% women) and 2972 Asian (64% women) Singapore Longitudinal Aging Study participants (mean age 66 years in both) free of myocardial infarction or heart failure. Racial differences in ECG characteristics and effect on mortality were assessed. In linear regression models, PR interval was longer in Asians compared with Whites (multivariable-adjusted β±SE 5.0±1.4 ms in men and 6.6±0.9 ms in women, both P<0.0006). QT interval was shorter in Asian men (β±SE -6.2±1.2 ms, P<0.0001) and longer in Asian women (β±SE 3.6±0.9 ms, P=0.02) compared to White men and women, respectively. Asians had greater odds of having ECG left ventricular hypertrophy (LVH) compared with Whites (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.36-9.35 for men, OR 1.93, 95% CI 1.35-2.76 for women, both P<0.02). Over a mean follow-up of 11±3 years in Framingham and 8±3 years in Singapore, mortality rates were 24.5 and 13.4 per 1000 person-years among Whites and Asians, respectively. In Cox models, the presence of LVH had a greater effect on all-cause mortality in Asians compared with Whites (hazard ratio [HR] 2.66, 95% CI 1.83-3.88 vs HR 1.30, 95% CI 0.90-1.89, P for interaction=0.02). Conclusion: Our findings from two large community-based cohorts show prominent race differences in ECG characteristics between Whites and Asians, and also suggest a differential association with mortality. These differences may carry implications for race-specific ECG reference ranges and cardiovascular risk. © 2016 The Authors. | Source Title: | Journal of the American Heart Association | URI: | https://scholarbank.nus.edu.sg/handle/10635/176003 | ISSN: | 2047-9980 | DOI: | 10.1161/JAHA.115.002956 |
Appears in Collections: | Elements Staff Publications |
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