Please use this identifier to cite or link to this item:
https://doi.org/10.1161/JAHA.115.002956
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dc.title | Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians | |
dc.contributor.author | Santhanakrishnan, R | |
dc.contributor.author | Wang, N | |
dc.contributor.author | Larson, M.G | |
dc.contributor.author | Magnani, J.M | |
dc.contributor.author | Vasan, R.S | |
dc.contributor.author | Wang, T.J | |
dc.contributor.author | Yap, J | |
dc.contributor.author | Feng, L | |
dc.contributor.author | Yap, K.B | |
dc.contributor.author | Ong, H.Y | |
dc.contributor.author | Ng, T.P | |
dc.contributor.author | Richards, A.M | |
dc.contributor.author | Lam, C.S.P | |
dc.contributor.author | Ho, J.E | |
dc.date.accessioned | 2020-09-14T07:41:38Z | |
dc.date.available | 2020-09-14T07:41:38Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Santhanakrishnan, R, Wang, N, Larson, M.G, Magnani, J.M, Vasan, R.S, Wang, T.J, Yap, J, Feng, L, Yap, K.B, Ong, H.Y, Ng, T.P, Richards, A.M, Lam, C.S.P, Ho, J.E (2015). Racial differences in electrocardiographic characteristics and prognostic significance in Whites versus Asians. Journal of the American Heart Association 5 (3) : e002956. ScholarBank@NUS Repository. https://doi.org/10.1161/JAHA.115.002956 | |
dc.identifier.issn | 2047-9980 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/176003 | |
dc.description.abstract | Background: Racial differences in electrocardiographic (ECG) characteristics and prognostic significance among Whites and Asians are not well described. Methods and Results: We studied 2677 White Framingham Heart Study participants (57% women) and 2972 Asian (64% women) Singapore Longitudinal Aging Study participants (mean age 66 years in both) free of myocardial infarction or heart failure. Racial differences in ECG characteristics and effect on mortality were assessed. In linear regression models, PR interval was longer in Asians compared with Whites (multivariable-adjusted β±SE 5.0±1.4 ms in men and 6.6±0.9 ms in women, both P<0.0006). QT interval was shorter in Asian men (β±SE -6.2±1.2 ms, P<0.0001) and longer in Asian women (β±SE 3.6±0.9 ms, P=0.02) compared to White men and women, respectively. Asians had greater odds of having ECG left ventricular hypertrophy (LVH) compared with Whites (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.36-9.35 for men, OR 1.93, 95% CI 1.35-2.76 for women, both P<0.02). Over a mean follow-up of 11±3 years in Framingham and 8±3 years in Singapore, mortality rates were 24.5 and 13.4 per 1000 person-years among Whites and Asians, respectively. In Cox models, the presence of LVH had a greater effect on all-cause mortality in Asians compared with Whites (hazard ratio [HR] 2.66, 95% CI 1.83-3.88 vs HR 1.30, 95% CI 0.90-1.89, P for interaction=0.02). Conclusion: Our findings from two large community-based cohorts show prominent race differences in ECG characteristics between Whites and Asians, and also suggest a differential association with mortality. These differences may carry implications for race-specific ECG reference ranges and cardiovascular risk. © 2016 The Authors. | |
dc.source | Unpaywall 20200831 | |
dc.subject | aged | |
dc.subject | Article | |
dc.subject | Asian | |
dc.subject | cardiovascular risk | |
dc.subject | Caucasian | |
dc.subject | controlled study | |
dc.subject | electrocardiography | |
dc.subject | female | |
dc.subject | follow up | |
dc.subject | human | |
dc.subject | male | |
dc.subject | mortality rate | |
dc.subject | PR interval | |
dc.subject | priority journal | |
dc.subject | prognosis | |
dc.subject | QT interval | |
dc.subject | race difference | |
dc.subject | action potential | |
dc.subject | Asian continental ancestry group | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Caucasian | |
dc.subject | clinical trial | |
dc.subject | comparative study | |
dc.subject | epidemiology | |
dc.subject | ethnology | |
dc.subject | health disparity | |
dc.subject | heart muscle conduction system | |
dc.subject | heart rate | |
dc.subject | Hypertrophy, Left Ventricular | |
dc.subject | Kaplan Meier method | |
dc.subject | longitudinal study | |
dc.subject | Massachusetts | |
dc.subject | middle aged | |
dc.subject | mortality | |
dc.subject | multicenter study | |
dc.subject | multivariate analysis | |
dc.subject | pathophysiology | |
dc.subject | predictive value | |
dc.subject | prognosis | |
dc.subject | proportional hazards model | |
dc.subject | prospective study | |
dc.subject | risk assessment | |
dc.subject | risk factor | |
dc.subject | sex difference | |
dc.subject | Singapore | |
dc.subject | statistical model | |
dc.subject | time factor | |
dc.subject | very elderly | |
dc.subject | Action Potentials | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Asian Continental Ancestry Group | |
dc.subject | Cardiovascular Diseases | |
dc.subject | Electrocardiography | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Health Status Disparities | |
dc.subject | Heart Conduction System | |
dc.subject | Heart Rate | |
dc.subject | Humans | |
dc.subject | Hypertrophy, Left Ventricular | |
dc.subject | Kaplan-Meier Estimate | |
dc.subject | Linear Models | |
dc.subject | Longitudinal Studies | |
dc.subject | Male | |
dc.subject | Massachusetts | |
dc.subject | Middle Aged | |
dc.subject | Multivariate Analysis | |
dc.subject | Predictive Value of Tests | |
dc.subject | Prognosis | |
dc.subject | Proportional Hazards Models | |
dc.subject | Prospective Studies | |
dc.subject | Risk Assessment | |
dc.subject | Risk Factors | |
dc.subject | Sex Factors | |
dc.subject | Singapore | |
dc.subject | Time Factors | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.contributor.department | PSYCHOLOGICAL MEDICINE | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.description.doi | 10.1161/JAHA.115.002956 | |
dc.description.sourcetitle | Journal of the American Heart Association | |
dc.description.volume | 5 | |
dc.description.issue | 3 | |
dc.description.page | e002956 | |
dc.published.state | Published | |
Appears in Collections: | Elements Staff Publications |
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