Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12877-017-0668-0
Title: Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation
Authors: Koh A.S. 
Velmurugan B. 
Gao F. 
Tan R.S. 
Wong J.-I.
Teo L.L.Y. 
Keng B.M.H.
Chua S.J.M.
Yuan J.-M.
Koh W.-P. 
Cheung C. 
Keywords: biological marker
urokinase receptor
aged
blood
cardiac muscle
cell aging
diastole
Doppler echocardiography
female
heart contraction
human
male
middle aged
pathology
physiology
predictive value
procedures
receiver operating characteristic
Aged
Biomarkers
Cellular Senescence
Diastole
Echocardiography, Doppler
Female
Humans
Male
Middle Aged
Myocardial Contraction
Myocardium
Predictive Value of Tests
Receptors, Urokinase Plasminogen Activator
ROC Curve
Issue Date: 2017
Citation: Koh A.S., Velmurugan B., Gao F., Tan R.S., Wong J.-I., Teo L.L.Y., Keng B.M.H., Chua S.J.M., Yuan J.-M., Koh W.-P., Cheung C. (2017). Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation. BMC Geriatrics 17 (1) : 275. ScholarBank@NUS Repository. https://doi.org/10.1186/s12877-017-0668-0
Abstract: Background: SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart. Methods: We performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels. Results: We studied community adults (n=120, 37.5% female) (mean age: 70.3±9.3 years) without known cardiovascular disease (CVD). Participants with impaired myocardial relaxation were older (84% vs 59% were aged ?71 years, p=0.002), with more diabetes mellitus (27% vs 11%, p=0.034). SuPAR levels were higher among participants with impaired myocardial relaxation (3.9 ng/ml vs 3.0 ng/ml, p=0.015). At the univariate level, older age (OR 3.6; 95%CI 1.6, 8.5; p=0.003), diabetes mellitus (OR 3.04; 95%CI 1.1, 8.8; p=0.04), systolic blood pressure (OR 1.03; 95%CI 1.001, 1.1; p=0.041) and suPAR levels ?3.00ng/ml (OR 3.4; 95%CI 1.16, 7.4; p=0.002) were associated with impaired myocardial relaxation. In multivariable regression analysis, only older age (OR 2.8; 95%CI 1.1, 6.7; p=0.026) and suPAR (OR 2.7; 95%CI 1.2, 6.1; p=0.018) remained independently associated with impaired myocardial relaxation. Receiver operating characteristics (ROC) curve analysis revealed an area under the curve (AUC) value of 0.63 (95% CI 0.54, 0.71) for model that included age alone. Addition of suPAR significantly increased AUC value to 0.70 (95%CI 0.60, 0.79), which was significantly larger than the model with age alone (p=0.016). Conclusion: We demonstrate additional ability of suPAR, over age, to predict impaired myocardial relaxation. Trial registration: ClinicalTrials.gov Identifier: NCT02791139 (Registered May 31, 2016). © 2017 The Author(s).
Source Title: BMC Geriatrics
URI: https://scholarbank.nus.edu.sg/handle/10635/175414
ISSN: 1471-2318
DOI: 10.1186/s12877-017-0668-0
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