Please use this identifier to cite or link to this item: https://doi.org/10.3389/fpsyt.2018.00558
Title: Minocycline attenuates stress-induced behavioral changes via its anti-inflammatory effects in an animal model of post-traumatic stress disorder
Authors: Wang, W
Wang, R
Xu, J
Qin, X
Jiang, H
Khalid, A
Liu, D
Pan, F
Ho, C.S.H
Ho, R.C.M 
Keywords: immunoglobulin enhancer binding protein
minocycline
animal experiment
animal model
animal tissue
antiinflammatory activity
Article
behavior change
cell activation
cognitive defect
controlled study
down regulation
elevated plus maze test
hippocampus
learning disorder
male
microglia
Morris water maze test
nonhuman
open field test
posttraumatic stress disorder
prefrontal cortex
rat
Issue Date: 2018
Citation: Wang, W, Wang, R, Xu, J, Qin, X, Jiang, H, Khalid, A, Liu, D, Pan, F, Ho, C.S.H, Ho, R.C.M (2018). Minocycline attenuates stress-induced behavioral changes via its anti-inflammatory effects in an animal model of post-traumatic stress disorder. Frontiers in Psychiatry 9 (NOV) : 558. ScholarBank@NUS Repository. https://doi.org/10.3389/fpsyt.2018.00558
Abstract: Accumulating evidences have suggested that anxiety-like behavior and impairment of learning and memory are key symptoms of posttraumatic stress disorder (PTSD), and pharmacological treatment can ameliorate anxiety and cognitive impairments. Recent studies have shown that minocycline exhibits anxiolytic effects. The aims of the present study were to determine whether minocycline administration would alter anxiety-like behavior and cognitive deficits induced by inescapable foot shock (IFS) and to explore the underlying mechanisms. Male Wistar rats were exposed to the IFS protocol for a period of 6 days to induce PTSD. The PTSD-like behavior was tested using the open field test, elevated plus maze test, and Morris water maze test. The effects of minocycline on pro-inflammatory cytokines, activation of microglia, and NF-?B in the PFC and hippocampus were also examined. Treatment with minocycline significantly reversed the IFS induced behavioral and cognitive parameters (impaired learning and memory function) in stressed rats. Additionally, IFS was able to increase proinflammatory cytokines, activate microglia, and enhance NF-?B levels, while minocycline significantly reversed these alterations. Taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and NF-?B in the PFC and hippocampus. Copyright © 2018 Wang, Wang, Xu.
Source Title: Frontiers in Psychiatry
URI: https://scholarbank.nus.edu.sg/handle/10635/175358
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2018.00558
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