Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fpsyt.2018.00558
DC Field | Value | |
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dc.title | Minocycline attenuates stress-induced behavioral changes via its anti-inflammatory effects in an animal model of post-traumatic stress disorder | |
dc.contributor.author | Wang, W | |
dc.contributor.author | Wang, R | |
dc.contributor.author | Xu, J | |
dc.contributor.author | Qin, X | |
dc.contributor.author | Jiang, H | |
dc.contributor.author | Khalid, A | |
dc.contributor.author | Liu, D | |
dc.contributor.author | Pan, F | |
dc.contributor.author | Ho, C.S.H | |
dc.contributor.author | Ho, R.C.M | |
dc.date.accessioned | 2020-09-09T09:52:20Z | |
dc.date.available | 2020-09-09T09:52:20Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Wang, W, Wang, R, Xu, J, Qin, X, Jiang, H, Khalid, A, Liu, D, Pan, F, Ho, C.S.H, Ho, R.C.M (2018). Minocycline attenuates stress-induced behavioral changes via its anti-inflammatory effects in an animal model of post-traumatic stress disorder. Frontiers in Psychiatry 9 (NOV) : 558. ScholarBank@NUS Repository. https://doi.org/10.3389/fpsyt.2018.00558 | |
dc.identifier.issn | 1664-0640 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/175358 | |
dc.description.abstract | Accumulating evidences have suggested that anxiety-like behavior and impairment of learning and memory are key symptoms of posttraumatic stress disorder (PTSD), and pharmacological treatment can ameliorate anxiety and cognitive impairments. Recent studies have shown that minocycline exhibits anxiolytic effects. The aims of the present study were to determine whether minocycline administration would alter anxiety-like behavior and cognitive deficits induced by inescapable foot shock (IFS) and to explore the underlying mechanisms. Male Wistar rats were exposed to the IFS protocol for a period of 6 days to induce PTSD. The PTSD-like behavior was tested using the open field test, elevated plus maze test, and Morris water maze test. The effects of minocycline on pro-inflammatory cytokines, activation of microglia, and NF-?B in the PFC and hippocampus were also examined. Treatment with minocycline significantly reversed the IFS induced behavioral and cognitive parameters (impaired learning and memory function) in stressed rats. Additionally, IFS was able to increase proinflammatory cytokines, activate microglia, and enhance NF-?B levels, while minocycline significantly reversed these alterations. Taken together, our results suggest that the anxiolytic effect of minocycline is related to its ability to decrease the levels of pro-inflammatory cytokines and inhibit activation of microglia and NF-?B in the PFC and hippocampus. Copyright © 2018 Wang, Wang, Xu. | |
dc.source | Unpaywall 20200831 | |
dc.subject | immunoglobulin enhancer binding protein | |
dc.subject | minocycline | |
dc.subject | animal experiment | |
dc.subject | animal model | |
dc.subject | animal tissue | |
dc.subject | antiinflammatory activity | |
dc.subject | Article | |
dc.subject | behavior change | |
dc.subject | cell activation | |
dc.subject | cognitive defect | |
dc.subject | controlled study | |
dc.subject | down regulation | |
dc.subject | elevated plus maze test | |
dc.subject | hippocampus | |
dc.subject | learning disorder | |
dc.subject | male | |
dc.subject | microglia | |
dc.subject | Morris water maze test | |
dc.subject | nonhuman | |
dc.subject | open field test | |
dc.subject | posttraumatic stress disorder | |
dc.subject | prefrontal cortex | |
dc.subject | rat | |
dc.type | Article | |
dc.contributor.department | PSYCHOLOGICAL MEDICINE | |
dc.description.doi | 10.3389/fpsyt.2018.00558 | |
dc.description.sourcetitle | Frontiers in Psychiatry | |
dc.description.volume | 9 | |
dc.description.issue | NOV | |
dc.description.page | 558 | |
dc.published.state | Published | |
Appears in Collections: | Staff Publications Elements |
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