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Title: Markers of cardiac dysfunction in cognitive impairment and dementia
Authors: Hilal S. 
Chai Y.L. 
Ikram M.K. 
Elangovan S.
Yeow T.B. 
Xin X. 
Chong J.Y. 
Venketasubramanian N. 
Richards A.M. 
Chong J.P.C. 
Lai M.K.P. 
Chen C. 
Keywords: amino terminal pro brain natriuretic peptide
troponin T
biological marker
brain natriuretic peptide
peptide fragment
pro-brain natriuretic peptide (1-76)
troponin T
Age Related White Matter Changes Scale
assessment of humans
brain infarction
case control study
cerebrovascular disease
cognitive defect
congestive heart failure
controlled study
diabetes mellitus
disease association
heart atrium fibrillation
heart disease
heart infarction
major clinical study
nuclear magnetic resonance imaging
nuclear magnetic resonance scanner
priority journal
protein blood level
white matter lesion
middle aged
mild cognitive impairment
very elderly
Aged, 80 and over
Biological Markers
Case-Control Studies
Cerebrovascular Disorders
Magnetic Resonance Imaging
Middle Aged
Mild Cognitive Impairment
Natriuretic Peptide, Brain
Peptide Fragments
Troponin T
Issue Date: 2015
Publisher: Lippincott Williams and Wilkins
Citation: Hilal S., Chai Y.L., Ikram M.K., Elangovan S., Yeow T.B., Xin X., Chong J.Y., Venketasubramanian N., Richards A.M., Chong J.P.C., Lai M.K.P., Chen C. (2015). Markers of cardiac dysfunction in cognitive impairment and dementia. Medicine (United States) 94 (1) : e297. ScholarBank@NUS Repository.
Abstract: Markers of cardiac dysfunction such as amino terminal pro-brain natriuretic peptide (NTpro-BNP) and high sensitivity cardiac troponin T (hs-cTnT) may be associated with dementia. However, limited data exist on their association with either pre-dementia stages, that is, cognitive impairment no dementia (CIND), or the burden of cerebrovascular diseases (CeVD).We therefore, examined the association of these biomarkers of cardiac dysfunction with CeVD in both CIND and dementia.A case-control study, with cases recruited from memory clinics and controls from memory clinics and community. All subjects underwent collection of blood samples, neuropsychological assessment, and neuroimaging. Subjects were classified as CIND and dementia based on clinical criteria whilst significant CeVD was defined as the presence of cortical infarcts and/or more than 2 lacunes and/or confluent white matter lesions in two regions of brain on Age-Related White Matter Changes Scale.We included a total of 35 controls (mean age: 65.9 years), 78 CIND (mean age: 70.2 years) and 80 cases with dementia (mean age: 75.6 years). Plasma concentrations of hs-cTnT were associated significantly with CeVD in both CIND (odds ratios [OR]: 9.05; 95% confidence interval [CI]: 1.64-49.79) and dementia (OR: 16.89; 95%CI: 2.02-142.67). In addition, NTpro-BNP was associated with dementia with CeVD (OR: 7.74; 95%CI: 1.23-48.58). These associations were independent of other vascular risk factors.In this study, we showed that plasma NTproBNP and hs-cTnT are associated with dementia and CIND, only when accompanied by presence of CeVD. © 2015 Wolters Kluwer Health, Inc.
Source Title: Medicine (United States)
ISSN: 0025-7974
DOI: 10.1097/MD.0000000000000297
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