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Title: Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI
Authors: Qiu, Y
Liu, S 
Hilal, S
Loke, Y.M 
Ikram, M.K 
Xu, X 
Yeow Tan, B
Venketasubramanian, N 
Chen, C.L.-H 
Zhou, J 
Keywords: aged
Alzheimer disease
case control study
cognitive defect
corpus callosum
diagnostic imaging
diffusion tensor imaging
memory disorder
nerve tract
neuropsychological test
nuclear magnetic resonance imaging
Alzheimer Disease
Case-Control Studies
Cognitive Dysfunction
Corpus Callosum
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Memory Disorders
Neural Pathways
Neuropsychological Tests
Issue Date: 2016
Publisher: Nature Publishing Group
Citation: Qiu, Y, Liu, S, Hilal, S, Loke, Y.M, Ikram, M.K, Xu, X, Yeow Tan, B, Venketasubramanian, N, Chen, C.L.-H, Zhou, J (2016). Inter-hemispheric functional dysconnectivity mediates the association of corpus callosum degeneration with memory impairment in AD and amnestic MCI. Scientific Reports 6 : 32573. ScholarBank@NUS Repository.
Abstract: Evidences suggested that both corpus callosum (CC) degeneration and alternations of homotopic inter-hemispheric functional connectivity (FC) are present in Alzheimer's disease (AD). However, the associations between region-specific CC degeneration and homotopic inter-hemispheric FC and their relationships with memory deficits in AD remain uncharacterized. We hypothesized that selective CC degeneration is associated with memory impairment in AD and amnestic mild cognitive impairment (aMCI), which is mediated by homotopic inter-hemispheric functional dysconnectivity. Using structural magnetic resonance imaging (MRI) and task-free functional MRI, we assessed the CC volume and inter-hemispheric FC in 66 healthy controls, 41 aMCI and 41 AD. As expected, AD had CC degeneration and attenuated inter-hemispheric homotopic FC. Nevertheless, aMCI had relatively less severe CC degeneration (mainly in mid-anterior, central, and mid-posterior) and no reduction in inter-hemispheric homotopic FC. The degeneration of each CC sub-region was associated with specific inter-hemispheric homotopic functional disconnections in AD and aMCI. More importantly, impairment of inter-hemispheric homotopic FC partially mediated the association between CC (particularly the central and posterior parts) degeneration and memory deficit. Notably, these results remained after controlling for hippocampal volume. Our findings shed light on how CC degeneration and the related inter-hemispheric FC impact memory impairment in early stage of AD.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/srep32573
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